兰屿树杞(Ardisia cf. elliptica)三萜及其抑制鸭(Anas platyrynchos L.)绒毛尿囊膜血管生成作用(英文)  

Angio-suppressive triterpenoids from Ardisia cf.elliptica (subgenus Tinus)on duck(Anas platyrynchos L.) chorioallantoic membrane

作　　者：Dennis D. Raga Annabelle A. Herrera Consolacion Y. Ragasa 

机构地区：[1]Biology Department, School of Science and Engineering, Ateneo de Manila University [2]Institute of Biology, University of the Philippines [3]Chemistry Department and Center for Natural Sciences and Ecological Research, De La Salle University

出　　处：《中国天然药物》2013年第2期128-138,共11页

基　　金：supported by the grant from the Philippine Council for Health Research and Development (PCHRD) of the Philippines through the Metro Manila Health Research and Development Consortium (MMHRDC)

摘　　要：The dichloromethane extract of the air-dried leaves of Ardisia cf.elliptica(subgenus Tinus)afforded a mixture of bauerenol(1a),α-amyrin(1b)andβ-amyrin(1c).Their structures were identified by NMR spectroscopy.Mixtures of the triterpenes (1a-1c)at ratios of 2:2:1,2:2:3 and 1:1:1 were tested for their angio-suppressive effects on duck chorioallantoic membrane (CAM).All three ratios were found to be effective in restricting inter-capillary length,while 1a-1c(2:2:1)was most effective in reducing branch point density with 100%CAM viability and embryo survivability,suggesting a high impact angio-suppressive potential of 1a-1c(2:2:1).The dichloromethane extract of the air-dried leaves ofArdisia cf. elliptica （subgenus Tinus） afforded a mixture of bauerenol （la）, a-amyrin （lb） and β-amyrin （le）. Their structures were identified by NMR spectroscopy. Mixtures of the triterpenes （la-le） at ratios of 2 ： 2 ： 1, 2 ： 2 ： 3 and 1 ： 1 ： 1 were tested for their angio-suppressive effects on duck chorioallantoic membrane （CAM）. All three ratios were found to be effective in restricting inter-capillary length, while la-le （2 ： 2 ： 1） was most effective in reducing branch point density with 100% CAM viability and embryo survivability, suggesting a high impact angio-suppressive potential of la-lc （2 ： 2 ： 1）.

关 键 词：Ardisia cf.elliptica(subgenus Tinus) MYRSINACEAE Bauerenol α-Amyrin β-Amyrin Angio-suppressive 

分 类 号：R965[医药卫生—药理学]