Trichosanthes dioica根的神经药理特点(英文)  

Neuropharmacological properties of Trichosanthes dioica root

作　　者：Sanjib Bhattacharya Pallab KantiHaldar 

机构地区：[1]Bengal School of Technology (A College of Pharmacy) [2]Department of Pharmaceutical Technology, Jadavpur University

出　　处：《中国天然药物》2013年第2期158-163,共6页

摘　　要：AIM: Trichosanthes dioica Roxb. (Cucurbitaceae), commonly known as pointed gourd in English, is a dioecious climber grown widely in the Indian subcontinent. Traditionally, this plant has been used in India for several medicinal purposes. The present study aimed to evaluate certain neuropharmacological properties of the hydroalcoholic extract of T. dioica root (TDA) in experimental animal models. METHODS: TDA (at 100 and 200 mg·kg-1 body weight, p.o.) was evaluated for anti-nociceptive activity by the acetic acid-induced writhing and tail flick methods. Locomotor depressant activity was measured by means of an actophotometer. Skeletal muscle relaxant effects were evaluated by using a rota-rod apparatus, and the sedative potentiating property by a phenobar-bitone-induced sleep potentiation study. RESULTS: The results of the present study revealed significant (P<0.001) and dose dependent anti-nociceptive, locomotor depressant, muscle relaxant, and sedative potentiating effects of TDA, demonstrating its depressant action on the central nervous system (CNS). CONCLUSION: From the present study, it can be concluded that T. dioica root possessed prominent anti-nociceptive, as well as depressant, action on the CNS, as manifested by these important neuropharmacological properties in mice.AIM： Trichosanthes dioica Roxb. （Cucurbitaceae）, commonly known as pointed gourd in English, is a dioecious climber grown widely in the Indian subcontinent. Traditionally, this plant has been used in India for several medicinal purposes. The present study aimed to evaluate certain neuropharmacological properties of the hydroalcoholic extract of T. dioica root （TDA） in experimental animal models. METHODS： TDA （at 100 and 200 mg.kg t body weight, p.o.） was evaluated for anti-nociceptive activity by the acetic acid-induced writhing and tail flick methods. Locomotor depressant activity was measured by means of an actophotometer. Skeletal muscle relaxant effects were evaluated by using a rota-rod apparatus, and the sedative potentiating property by a phenobarbitone-induced sleep potentiation study. RESULTS： The results of the present study revealed significant （P 〈 0.001） and dose dependent anti-nociceptive, locomotor depressant, muscle relaxant, and sedative potentiating effects of TDA, demonstrating its depressant action on the central nervous system （CNS）. CONCLUSION： From the present study, it can be concluded that T. dioica root possessed prominent anti-noeiceptive, as well as depressant, action on the CNS, as manifested by these important neuropharmacological properties in mice.

关 键 词：Trichosanthes dioica CNS depressant LOCOMOTOR Muscle relaxant PHENOBARBITONE 

分 类 号：R965[医药卫生—药理学]