耐药肺炎支原体感染患儿的用药分析  

Regimen analysis of children infected by macrolide-resistant mycoplasma pneumoniae

作　　者：王穗琼[1] 王豫[1] 邓文喻[1] 张琳[1] 

机构地区：[1]广东省妇幼保健院药学部,广州510010

出　　处：《医药论坛杂志》2013年第1期4-6,共3页Journal of Medical Forum

基　　金：广东省科技厅计划项目(2011B031800226)

摘　　要：目的探讨耐大环内酯类抗菌药的肺炎支原体感染患儿的用药方案。方法分析2010年11月至2012年5月广东省妇幼保健院收治的咽拭子肺炎支原体培养阳性患儿的用药方案,并回访用药疗程。结果 MP培养阳性患儿116例均使用了大环内酯类抗菌药抗感染治疗,其中耐药52例,除去3例联合了β内酰胺类抗菌药,耐药组为49例;敏感组为64例,没有联合β内酰胺类抗菌药病例。两组的年龄、性别,大环内酯类抗菌药、解热药、抗组胺药、化痰药的使用率差异无统计学意义,P>0.05。耐药组大环内酯类抗菌药的疗程短于敏感组,而解热药、抗组胺药和化痰药的疗程均长于敏感组,差异有统计学意义,P<0.05。结论耐大环内酯类抗菌药的肺炎支原体感染患儿采用大环内酯类抗菌药、解热药、抗组胺药和化痰药治疗,与大环内酯类抗菌药敏感的肺炎支原体感染患儿相比,耐药患儿使用大环内酯类抗菌药的疗程短,使用解热药、抗组胺药和化痰药的疗程长。Objective To explore the regimen of children infected by macrolide - resistant mycoplasma pneumoniae. Methods The regimens were analyzed of children whose throat swab mycoplasma pneumoniae cultures were positive, from November 2010 to May 2012 in our hospital. And the courses of medications were returned visits. Results There were 116 children whose throat swab mycoplasma pneumoniae cultures were positive. All of them took macrolide antibacterial agents. In addition to three children combined β - lactam antibacterials, there were 49 children in the drug - resistant group of 52 children infected by macrolide - resistant mycoplasma pneumoniae. There were 64 children in the drug - susceptive group. No significant differences were found in sex, age, usage rates of macrolide antibacterial agents, antipyretic drugs, antihistamines and phlegm drugs, P 〉 0. 05. Compared to drug - susceptive group, the courses of macrolide antibacterial agents were shorter, and antipyretic drugs, antihistamine drugs and apophlegmatisants were lon- ger in the drug - resistant group, P 〈 0. 05. Conclusions The children infected by macrolide - resistant mycoplasma pneumoniae treated by antipyretic drugs, antihistamine drugs and apophlegmatisants. Compared to the children infected by macrolide - susceptive mycoplasma pneumoniae, the children infected by macrolide - resistant had shorter course of macrolide antibacterial agents, and longer courses of antipyretic drugs, antihistamine drugs and apophlegmatisants.

关 键 词：耐药性 大环内酯类抗菌药 肺炎支原体 患儿 

分 类 号：R725.6[医药卫生—儿科]