喹喃克林凝胶对大鼠子宫腔堵塞后解剖及组织病理学观察  

Anatomical and pathological changes in rat uterine cavity after blocked with quinacrine chitosan gel

作　　者：刘静 杨燕 于玲 吴喜梅 许观照 李欣迎 宋燕 胥玉梅 陶国振 孙林 高爱萍 张艳 王鲁沂 

机构地区：[1]山东省计划生育科研所,山东省优生技术重点实验室,济南250002

出　　处：《中国计划生育学杂志》2013年第3期166-169,共4页Chinese Journal of Family Planning

摘　　要：目的:了解喹喃克林几丁糖凝胶一次性使用对大鼠子宫腔的堵塞作用及子宫组织病理改变。方法:将不同浓度的喹喃克林几丁糖凝胶注入大鼠子宫腔内,并以宫腔注入复方苯酚糊大鼠为对照,解剖和病理切片观察大鼠子宫腔纤维化增生情况及局部和周围组织器官反应变化。结果:大鼠子宫腔内一次性注入35%喹喃克林几丁糖凝胶,4周后宫腔完全被空泡化的基质细胞和成纤维细胞堵塞,6周后宫腔完全被肉芽组织堵塞,阻塞效果与复方苯酚糊组相同。病理解剖结果显示大鼠管腔无局部及邻近组织炎性反应。结论:一次性注入35%浓度的喹喃克林几丁糖凝胶对大鼠子宫腔有明显的阻塞作用,生殖管腔无炎性反应,可作为一种非手术绝育法继续研究。Objective： To observe the effect of quinacrine chitosan gel （QCG） on the blockage of rat uterine cavity and the resultant pathological changes. Methods： OCG at concentration of 35% was iniected into rat uterine cavity, with Dhenolatabrine paste （PAP） as control. The uterine horns were collected 4 and 6 weeks later to observe the anatomical and pathological changes. Results ： The rat uterine cavity was filled with vacuolated stromal cells and fibroblasts 4 weeks after an injection of QCG,and completely jammed with granulation tissue 6 weeks after the injection, which was similar to effect of PAP. No inflammatory reaction was found in the uterine cavity or the adjacent tissues. Conclusion： QCG had an obvious effect of uterine cavity blockage without any inflammatory reaction, and may be as a novel non - surgical contraceptive method for the women of reproductive age.

关 键 词：喹喃克林几丁糖 大鼠子宫 复方苯酚糊 非手术绝育 病理改变 

分 类 号：R965[医药卫生—药理学]