乙交酯-丙交酯共聚物精制过程中有机锡的去除方法  

Removal of Organotin During Purification Process of Poly(lactic-co-glycolic acid)

作　　者：杨莉[1] 栾瀚森[1] 徐凤兰[1] 王浩[1] 

机构地区：[1]上海现代药物制剂国家工程研究中心有限公司,上海201203

出　　处：《中国医药工业杂志》2013年第3期235-237,共3页Chinese Journal of Pharmaceuticals

基　　金：国家"重大新药创制"科技重大专项(2011ZX09401-403-1);上海市科学技术委员会科研计划项目注射用可生物降解药用辅料的产业化研究(10dz2211900);注射用可生物降解药用辅料PLGA的产业化研究(2011ZX09401-403-1);新型缓控释药用辅料开发与应用的关键技术(2011ZX09501-003)

摘　　要：在乙交酯-丙交酯共聚物(PLGA)精制过程中,比较了采用稀酸溶液和有机溶剂为萃取剂对聚合物中有机锡的去除效果,并考察了以有机溶剂为萃取剂时各工艺参数对精制效果的影响。结果表明,将PLGA溶于乙腈中配成1%的溶液后用等体积石油醚萃取3次,所得产品中锡残留量低于10 g/g。该法能有效避免酸性条件下PLGA的降解,不使用无机酸。The residual tin in poly （lactic-co-glycolic acid） （PLGA） after purification by dilute acid solution or organic solvent extraction was determined to compare the removal efficiency of the two methods. The influences in the organic solvent extraction process on the residual tin were investigated. The results showed that the residual tin was less than 10μg/g when the 1% PLGA acetonitrile solution was extracted with the equal volume of petroleum ether for three times. This method without inorganic acid could avoid the degradation of PLGA.

关 键 词：乙交酯-丙交酯共聚物 精制 萃取 有机锡 

分 类 号：TQ314.2[化学工程—高聚物工业]