胃疡宁丸抗实验性胃溃疡的药效及机制研究  

Study on efficacy and mechanism of Weiyangning pills against experimental gastric ulcer

作　　者：徐晶晶[1] 黄萍[1] 吴清和[1] 操红缨[1] 文思[1] 刘静[1] 

机构地区：[1]广州中医药大学,广东广州510006

出　　处：《中国中药杂志》2013年第5期736-739,共4页China Journal of Chinese Materia Medica

摘　　要：目的:研究胃疡宁丸抗实验性胃溃疡的药效及其机制。方法:采用大鼠醋酸注射法、水浸应激性、阿司匹林诱发及幽门结扎性胃溃疡模型,观察胃疡宁丸抗胃溃疡的作用并考察其对血清NO,EGF含量,胃黏膜血流量,PGE2含量,及对胃液分泌、胃酸含量、胃蛋白酶活性的影响。结果:胃疡宁丸能够降低各种胃溃疡模型的溃疡指数,升高NO,EGF含量,PGE2含量及胃黏膜血流量,抑制胃液分泌和胃酸含量及降低胃蛋白酶活性。结论:胃疡宁丸具有明显的抗实验性胃溃疡的作用,该作用与其减少胃黏膜损伤因子(胃酸、胃蛋白酶),增加胃黏膜屏障的功能,增强胃黏膜修复作用(NO,EGF,PGE2,胃黏膜血流量)有关。Objective： To study the efficacy and mechanism of Weiyangning pills against experimental gastric ulcer. Method： The gastric ulcer model were established by acetic acid, water-immersion stress, aspirin induction, pyloric ligation in rats, in order to observe the effect of Weiyangning pills against experimental gastric ulcer and study its effect on the content of nitric oxide （NO） and epidermal growth factor （EGF）, gastric mucosal blood flow, the content of PGE2 , gastric secretion, gastric acid content and the activi- ty of pepsin. Result： Weiyangning pills markedly reduced index of gastric ulcers of various types, increased the content of NO, EGF, PGE2 and gastric mucosal blood flow, inhibited gastric secretion and gastric acid content, and decreased the activity of pepsin. Conclu- sion： Weiyangning pills has a significant effect against experimental gastric ulcer, which is related to the reduction of gastric mucosa damage factors （gastric acid and pepsin） and the increase in gastric mucosa＇s function as a barrier and its recovery effects, such as NO, EGF, PGE2 and gastric mucosal blood flow.

关 键 词：胃疡宁丸 胃溃疡模型 溃疡指数 

分 类 号：R285.5[医药卫生—中药学]