长效注射剂释药技术研究进展  

Progress of drug delivery technologies for long-acting injections

作　　者：张芳[1,2] 杨志强[2] 王杏林[2] 

机构地区：[1]天津中医药大学,天津300193 [2]天津药物研究院释药技术与药动学国家重点实验室,天津300193

出　　处：《中国新药杂志》2013年第5期547-555,共9页Chinese Journal of New Drugs

基　　金：国家973课题(2010CB735602;2012CB724002)

摘　　要：随着科学技术的不断发展,人们对药物治疗作用的要求越来越高。长效注射剂因可延长药物的作用时间、减少注射次数、改善患者的顺应性而成为当前药剂研究的一大热点。本文以释药技术为主线,综述了前体药物技术、PEG化技术、微球技术、难溶盐技术、注射植入剂、DepoFoam技术、温敏型原位凝胶等释药技术在长效注射剂中的应用。With the constant development of science and technology, people＇s demand for drug therapy effect has become higher and higher. Due to the fact that long-acting injection can prolong the action time, reduce the frequency of administration and improve the patient compliance, it has become a hot area of pharmaceutic research. In this review, we introduced sustained-release drug delivery systems and reviewed the application of the technologies such as prodrug, PEGylation, microspheres, insoluble salts technology, injectable implants, Depo- Foam technology and temperature-sensitive in situ gel in the development of long-acting injections.

关 键 词：长效注射剂 前体药物技术 PEG化技术 微球技术 DepoFoam技术 

分 类 号：R943[医药卫生—药剂学]