细胞功能调控的重要转录因子TFEB  

Function and regulation of the transcription factor TFEB

作　　者：陈太琪[1] 姜丛[1] 王平[1] 刘宁[1,2] 

机构地区：[1]华东师范大学生命科学学院生命医学研究所,上海200241 [2]杭州师范大学医学部衰老研究所,杭州310036

出　　处：《生命的化学》2013年第1期53-57,共5页Chemistry of Life

摘　　要：转录因子TFEB(transcription factor EB)属于亮氨酸拉链bHLH-LZ(basic-helix-loop-helix leucine-zipper)类转录因子中的MiTF/TFE(microphthalmia-transcription factor E)家族成员,参与调控许多重要的细胞生理过程,例如胎盘血管新生、肾癌的发生等。最近研究表明,TFEB能通过调控细胞自噬和溶酶体相关的基因表达而调控细胞自噬以及溶酶体功能。因此,对于TFEB的生物学功能及其相关调控机制的研究,将为进一步阐释其生理病理发生过程及相关疾病的治疗提供重要的线索及理论依据。TFEB is a member of the MiTF/TFE （microphthalmia-transcription factor E） subtamlly ot bHLH-LZ （basic-helix-loop-helix leucine-zipper） factors. And TFEB-related pathway is involved in some of cellular physiological processes and its regulating aberration has been known to contribute to the pathogenesis of several human diseases, such as placenta angiogenesis and renal cell carcinoma. Recent studies have shown that TFEB could regulate autophagy and lysosome function through regulating the expression of the related genes. Future study on the function and mechanism of TFEB will help better understand the pathological process and provide new theory basis and clues for the treatment of TFEB-related diseases.

关 键 词：转录因子TFEB 自噬 溶酶体 

分 类 号：Q75[生物学—分子生物学]