新型环内酯类氮氧杂环蕃的合成及表征  

Synthesis and characterization of novel macrolides N,O-containing heterocyclophane

作　　者：方线文[1] 周丽珍[1] 杨美盼[1] 成昭[1] 杨秉勤[1] 

机构地区：[1]西北大学合成与天然功能分子化学教育部重点实验室,陕西西安710069

出　　处：《化学试剂》2013年第3期197-200,256,共5页Chemical Reagents

基　　金：国家自然科学基金资助项目(21172178)

摘　　要：以取代芳胺及萘胺为原料,经羟乙基化反应制得相应的二醇后,在高度稀释条件下,与邻苯二甲酰氯反应制得3种新型环内酯类氮氧杂环蕃。其结构用IR、1HNMR、ESI-HRMS、X-ray进行了表征,同时X-ray分析表明了邻苯二甲酸-(3-乙酰苯基)-N,N-二乙醇双内酯的晶体结构属单斜晶系,P2(1)/c空间群。A kind of novel macrolides N,O-containing hetero- cyclophane was successfully synthesized by the reaction of o-phthaloyl chloride with substituted diols at high dilution con- dition,wherein the diols can be obtained by hydroxyethylation of the naphthylamine and the substituted arylamine. The structure of title compounds has been confirmed by IR, L HNMR,and ESI-HRMS. The X-ray diffraction analysis indicated that the crystal structure of compound belongs to the monoclinic system,P2（ 1 ）/c space group.

关 键 词：氮氧杂环蕃 羟乙基化 高度稀释法 合成 晶体结构 

分 类 号：O626[理学—有机化学]