分子伴侣Tapasin在介导特异性细胞毒性T淋巴细胞反应中的作用  

The role of the endoplasmic reticulum chaperone tapasin in mediating specific CTL responses

作　　者：唐余燕[1] 陈小华[1] 余永胜[1] 

机构地区：[1]上海交通大学附属第六人民医院感染科,上海200233

出　　处：《中国临床药理学与治疗学》2013年第2期212-216,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金项目(31000414)

摘　　要：病毒及肿瘤细胞的清除很大程度上依赖于特异性CD8+细胞毒性T淋巴细胞(CTL),CTL通过T细胞受体(TCR)特异性识别病毒肽段并通过MHC-I类分子提呈引起感染细胞融解,经典MHC-I类分子在内质网内的装配要求有抗原肽配体和β2微球蛋白(β2m)的存在,而这一过程需要伴侣分子(chaperones)如Tapasin的参与。Tapasin是抗原递呈相关转运体(TAP)相关蛋白的基因产物,与MHC-I类分子同为免疫球蛋白超家族成员,在介导特异性CTL反应中有着重要作用,本文简述了Tapasin分子结构特征、在介导特异性CTL反应中的作用及与疾病的联系。The clearing of virus and tumor cell a large degree relied on Specific CD8 ＋ cyto- toxic T lymphocytes （cytotoxie T cell, CTL）. CTL recognised virus peptide paragraph through T cell receptor （TCR） and caused infection cell melting through MHC-I class molecular presen- ting. The assembly of classic MHC-I molecular composition in endoplasmic reticulum （ER） re- quired antigen peptide ligand and beta 2m, and this process need chaperones such as tapasin. Tapasin was offspring of transporters associated with antigen processing （TAP） and a member of the immunoglobulin superfamily as well as MHC-I. Tapasin as molecular bridges between TAP and MHC-I, have an important role in me- diated specific CTL reactions. This review re- sumes its biological characteristics, the role in mediated specific CTL reactions and contacting with diseases.

关 键 词：TAPASIN 细胞毒性T淋巴细胞 MHC-I类分子 抗原加工 

分 类 号：R966[医药卫生—药理学]