姜黄素对大鼠慢性萎缩性胃炎的药效学研究  

The Pharmacodynamic Study of Curcumin on Chronic Atrophic Gastritis in Rats

作　　者：罗燕[1] 黄清松[2] 陈东波[2] 

机构地区：[1]广东省东莞市疾病预防控制中心,东莞523000 [2]广东药学院基础学院,广州510006

出　　处：《江西中医学院学报》2012年第4期58-60,共3页Journal of Jiangxi College of Traditional Chinese Medicine

摘　　要：目的:观察姜黄素对大鼠慢性萎缩性胃炎的治疗作用;初步探讨姜黄素作用大鼠慢性萎缩性胃炎的机制。方法:将大鼠随机分为6组:姜黄素高浓度组、中浓度组、低浓度组、维酶素组、模型组和正常对照组,正常对照组只用生理盐水灌胃,其余各组先用50℃脱氧胆酸钠连续灌胃6个月建立大鼠慢性萎缩性胃炎(CAG)模型,用对应的药物治疗6周,模型组除外。然后检测胃粘膜血流量,检测各组胃粘膜组织的病理变化,并检测SOD活性。结果:用姜黄素高剂量组和中剂量组治疗后的胃粘膜组织接近正常;与模型组比,姜黄素各组胃粘膜血流量和SOD活性均明显升高(P<0.05;P<0.01),并呈现一定的剂量依赖关系。结论:姜黄素对大鼠CAG具有较好的疗效,并存在一定的剂量依赖关系,其作用机制可能与增加胃粘膜血流量和抗氧化有关。Objective： It is to observe the function and mechanism of curcumin on chronic atrophic gastritis in rats. Methods： The rats were randomly divided into 6 groups： the high dose curcumin group, the medium dose curcumin group, the low dose eurcumin group, the vitacoenzyme group, the model group and the normal control group, Except the normal control group received intragastrical administration of normal saline. The rest five groups were made into CAG models by feeding sodium deoxyeholate of 50℃ for 6 months. With the exception of model group, Corresponding medication was administered to each group for 6 weeks. Then the gastric nmcosal hlood flow, pathological changes of gastric mucosal and SOD activity were detected. Results： There is no marked meaning to the differentiation of gastric mucosal pathematology among the curcumin high dosage, medium dosage groups and the normal control group. Compared to modle group, the gastric mueosal blood flow and SOD activity in the curcumin group increased significantly （P〈 0.05, P〈0.01 ）, and it showed a dose-dependent relationship. Conclusion： Effect of curcumin on rat CAG has better curative effect and it showed a dose-dependent relationship. The mechanism may be associated with the increase in gastric mucosal blood flow and antioxidant.

关 键 词：姜黄素 慢性萎缩性胃炎(CAG) 药效学 

分 类 号：R285.5[医药卫生—中药学]