子痫前期患者血清MCP-1和CRP的变化及意义  

Serum levels of monocyte chemoattractant protein-1 and c-reactive protein in patients with preeclampsia and their significance

作　　者：林力华[1] 

机构地区：[1]莆田学院附属医院妇产科,福建莆田351100

出　　处：《泰山医学院学报》2012年第9期674-676,共3页Journal of Taishan Medical College

摘　　要：目的通过分析比较子痫前期患者和正常孕妇血清中MCP-1和CRP的水平差异,探讨炎症反应与子痫前期的关系。方法选择180例轻度子痫前期患者、70例重度子痫前期患者和200例正常晚孕妇女做为研究对象,采用酶联免疫吸附法(ELISA)检测患者血清MCP-1水平,采用免疫散射比浊法检测患者血清CRP水平。结果 (1)子痫前期患者血清中MCP-1和CRP的水平均高于正常妊娠组,差异有统计学意义(P<0.01),且随着病情加重而递增;(2)子痫前期患者血清MCP-1水平与血清CRP水平呈显著正相关(r=0.954,P<0.01)。结论子痫前期患者血清中MCP-1和CRP水平均升高,提示子痫前期可能与炎症性反应有关。Objective： To evaluate serum levels of monocyte chemoattractant protein - 1 （ MCP - 1 ） and c - reactive protein （CRP） of preeelampsia and normal pregnant, thus to detect relationship with inflammation and preeclampsia. Methods ： 180 women with mild preeelampsia,70 women with severe preeclampsia and 200 normal pregnant women （ control group） were selected randomly in this study. The levels of serum MCP - 1 were determined by enzyme - linked immunosorbent assay. The levels of serum CRP were determined by immune scatter turbidimetry. Results ： （ 1 ） The levels of MCP - land CRP in sertma of the preeelampsia group was significantly higher than control group （P 〈 0. 01 ） ,which increased gradually with the condition getting more serious. （2） A significant positive correlation was observed between serum MCP - 1 level and CRP level of the preeelampsia group （ r = 0.954, P 〈 0.01 ） ; Conclusion ： The serum levels of MCP - 1 and CRP increased significantly of the preeelampsia group, which suggested that inflammation was associated with the occurrence and development of the preeelampsia.

关 键 词：先兆子痫 单核细胞化学吸引蛋白质1 C反应蛋白 胎盘 

分 类 号：R714.25[医药卫生—妇产科学]