纳米碳酸钙在馨月舒胶囊中应用的初步研究  

Study on Nano-CaCO_3 Applicated in Xin Yue Shu Capsules Preliminarily

作　　者：蒋艳荣[1,2] 张振海[1] 崔莉[1,2] 贺俊杰[1,2] 胡绍英[1,2] 贾晓斌[1,2] 

机构地区：[1]南京中医药大学药学院,江苏南京210046 [2]江苏省中医药研究院国家中医药管理局中药释系统重点研究室,江苏南京210028

出　　处：《中药材》2012年第11期1846-1850,共5页Journal of Chinese Medicinal Materials

基　　金：江苏省社会发展科技支撑计划(BE2010756);江苏省高等学校大学生创新训练计划项目(011042004000);江苏省中医药科技项目(LZ11065)

摘　　要：目的:考察纳米碳酸钙在馨月舒胶囊中的应用特性。方法:研究不同用量的纳米碳酸钙或微粉硅胶分别对馨月舒喷雾干燥粉体流动性、松密度、吸湿性、阿魏酸体外溶出度、阿魏酸稳定性的影响。结果:纳米碳酸钙和微粉硅胶均能显著提高馨月舒喷雾干燥粉体的流动性和松密度,对粉体的吸湿性、胶囊中阿魏酸的溶出度和稳定性无明显影响。结论:纳米碳酸钙提高中药喷雾干燥粉体流动性和松密度的作用值得进一步研究。Objective：To investigate the characteristics of nano-CaCO3 applicated in Xin Yue Shu Capsules. Methods： Studied the effect of different dosages of aerosil or nano-CaCO3 on fluidity, bulk density, moisture absorption of Xin Yue Shu capsules spray drying powder. In vitro dissolution and ferulic acid stability of Xin Yue Shu capsules was observed. Results： It significantly improved powder fluidity and bulk density of Xin Yue Shu spray drying powder when aerosil or nano-CaCO3 was added. But there was no significant effect on powder moisture absorption, ferulic acid in vitro dissolution and ferulic acid stability. Conclusion： The effect of Nano-CaCO3 on impro- ving powder fluidity and bulk density applicated in the spray drying powder of traditional Chinese medicine deserves studying further.

关 键 词：纳米碳酸钙 粉体 流动性 吸湿性 溶出度 

分 类 号：R944.5[医药卫生—药剂学]