家兔单肺通气雾化吸入氨溴索对非通气肺炎性反应的影响  

Effects of oxygen atomizing inhalation ambroxol on the inflammatory response to non-ventilatiedlung undergoing one lung ventilation in rabbits

作　　者：丁素春[1] 李明川[1] 李爱芝[1] 姜秀良[1] 黄海波[2] 

机构地区：[1]青岛大学医学院附属烟台毓璜顶医院麻醉科,烟台264000 [2]青岛大学医学院附属烟台毓璜顶医院胸外科,烟台264000

出　　处：《中华实验外科杂志》2013年第3期552-553,共2页Chinese Journal of Experimental Surgery

基　　金：烟台市科技发展计划资助项目

摘　　要：目的观察小剂量氨溴索经氧气驱动雾化吸人对家兔单肺通气（OLV）时非通气肺炎性反应的影响。方法健康家兔40只，随机分为双肺通气组（C组）、单肺通气组（OLV组）、静脉注射氨溴索组（IA组）、氧气驱动雾化吸入氨溴索组（IAI组）。c组行双肺通气2h，其余3组行右侧肺通气2h。IA组和AIA组分别在右肺通气前10min静注氨溴索15mg／k或采用自制装置氧气驱动雾化吸人氨溴索7．5mg。比较各组通气后左肺（非通气）支气管肺泡灌洗液中肿瘤坏死因子（TNF）-d、白细胞介素（IL）-1p、IL-8、IL-10浓度的变化。结果AIA组左肺灌洗液TNF—a、IL-1β、IL-8浓度分别为（69．88±18．54）、（61．54±10．92）、（49．53±8．28）ng／L，较OLV组[（16．04±1．41）、（3．46±0．27）、（16．87±1．73）ng／L]明显降低；IL-10浓度为（12．60±0．98）ng／L，较OLV组[（16．56±1．36）ng／L]明显升高（P〈0．01）。结论氨溴索小剂量氧气驱动雾化吸入，可有效抑制家兔OLV非通气侧肺内炎性反应。Objective To investigate the effects of oxygen atomizing inhalation of low dose ambr- oxol on the inflammatory response to non-ventilatied lung undergoing one lung ventilation （OLV）. Methods Fourty healthy rabbits were randomly divided into control group （ group C） receiving two-lung ventilation for two h, group OLV receiving right-lung ventilation for 2 h, group intravenous administration of ambroxol （IA） receiving intraveous injection of ambroxol 15 mg/kg, and group oxygen drive atomization inhalation of ambroxol （AIA） receiving oxygen atomizing inhalation of ambroxol 7.5 mg before right-lung ventilation for 2 h. The concentrations of tumor necrosis factor （TNF）-a, interleukin （IL）-113, IL-8, and IL-10 in left tracheal fluid were determined. Results TNF-oL, IL-113 and IL-8 concentrations in left tracheal fluid were （69. 88±18. 54）, （61.54 ± 10. 92 ）, and （49. 53 ± 8.28 ） ng/L respectively, which were significantly increased in group AIA as compared with those in group OLV [ （ 16.04 ± 1.41 ）, （ 3.46±0. 27 ）, and （ 16. 87 -± 1.73） ng/L] , while IL-10 concentration was （ 12. 60 ± 0. 98 ） ng/L, which was significantly higher in group AIA than in group OLV [ （ 16. 56 ± 1.36） rig/L] （ P 〈 0. O1 ）. Conclusion Oxygen atom- izing inhalation of low dose ambroxol can inhibit the inflammatory response to non-ventilatied lung undergo- ing OLV in rabbits.

关 键 词：氨溴索 呼吸 人工 炎症 兔 

分 类 号：R[医药卫生]