鸡眼睛乙酸乙酯部位化学成分研究  

Study on Chemical Constituents of Ethyl Acetate Fraction of Euscaphis japonica

作　　者：周雯[1] 刘智[2] 王海军[1] 李勇军[1] 王爱民[1] 许祖超 廖尚高[1] 

机构地区：[1]贵阳医学院药学院,贵阳550004 [2]贵阳医学院附属医院药剂科,贵阳550004 [3]贵州益康制药有限公司,贵阳550025

出　　处：《中国实验方剂学杂志》2013年第6期121-123,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技支撑计划项目(2006BAI06A01-03);贵州省中药现代化科技产业研究开发专项项目(黔科合中药字[2011]5081号;黔科合中药专字[2007]5014号);贵州省科技计划课题(黔科合计工字[2009]4001);贵阳市科学技术计划项目(2009筑科中合同字第9-3-04号)

摘　　要：目的:研究鸡眼睛乙醇提取物中等极性的乙酸乙酯萃取部位的化学成分,为民族药鸡眼睛的开发应用提供科学依据。方法:通过各种色谱分离技术对鸡眼睛乙醇提取物乙酸乙酯萃取部位进行分离纯化,根据化合物的理化性质和波谱数据鉴定其结构。结果:从鸡眼睛乙醇提取物乙酸乙酯萃取部位分离得到7个化合物,分别鉴定为:香草醛(vanillin,1),香草酸(vanillic acid,2),5-羟甲基糠醛(5-hydroxymethylfurfural,3),芥子醛(sinapic aldehyde,4),齐墩果酸(oleanolic acid,5),没食子酸(gallic acid,6),原儿茶酸(protocatechuic acid,7)。结论:其中化合物2～7为首次从该属植物中分离得到。Objective： To investigate the chemical constituents of the ethyl acetate fraction of ethanol extract of Euscaphis japonica. Method： Various preparative chromatographic techniques were used for the isolation and purification of the compounds and their structures were determined by comparison of their chromatographic and spectral data with those of the authentic samples and those reported in the literature. Result： Seven compounds were obtained and identified as vanillin（1）, vanillic acid（2）, 5-hydroxymethylfurfural（3）, sinapic aldehyde（4）, oleanolic acid（5）, gallic acid（6）, and protocatechuic acid（7）. Conclusion： Compounds 2-7 were isolated from the genus Euscaphis for the first time.

关 键 词：鸡眼睛 乙酸乙酯部位 化学成分 

分 类 号：R284.1[医药卫生—中药学]