桂枝茯苓胶囊辅助西药保守治疗异位妊娠40例  

Guizhi Fuling Capsules Supplemented to Western Medicine for Treating 40 Cases of Ectopic Pregnancy

作　　者：尹凤玲[1,2] 严春寅[1] 沈宗姬[1] 钱俊如 王维奇[2] 汤欣[2] 

机构地区：[1]苏州大学附属第一医院,江苏苏州215006 [2]徐州市中心医院,江苏徐州221009

出　　处：《中国实验方剂学杂志》2013年第6期317-319,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：徐州市科技局课题(XF10CO43)

摘　　要：目的:探讨桂枝茯苓胶囊辅助西药保守治疗异位妊娠的临床疗效。方法:80例异位妊娠患者随机分为观察组和对照组各40例。对照组采用米非司酮25 mg/次,口服,1次/12 h,连用3 d,总量150 mg;甲氨蝶呤(MTX)50 mg.m-2,总量分两侧臀部深部im 1次。观察组加服桂枝茯苓胶囊,口服,9粒/次,2次/d。共4周。监测血人绒毛膜促性腺激素(β-HCG)水平及包块变化情况,记录β-HCG降至正常及包块消失所需时间。结果:观察组保守成功35例(90.0%)优于对照组的29例(72.5%)(P<0.05);观察组血β-HCG平均恢复时间(14.5±7.7)d,少于对照组的(18.4±8.5)d(P<0.05);观察组3周内包块缩小32例,优于对照组的21例(P<0.05);观察组2周内临床症状消失34例,优于对照组的23例(P<0.05)。结论:桂枝茯苓胶囊配合甲氨蝶呤和米非司酮保守治疗异位妊娠,提高了保守治疗成功率,且临床使用安全。Objective： To investigate the curative effect of Guizhi Fuling capsules （GFC） supplemented to western medicine for treating ectopic pregnancy. Method： Eighty cases of ectopic pregnancy patients were randomly divided into the observation group and the control group, 40 cases in each group.Mifepristone was used in control group, 25 mg orally bid for 3 days; and methotrexate （MTX） 50 mg·m-2, deep intramuscular injection on both sides of the buttocks, once daily.On the basis of the control group, the observation group were received GFC 9 capsules bid for 4 weeks.Serum β-HCG level and mass changes were monitored, the β-HCG returned to normal and mass disappearance time required were recorded. Result： The conservative success rate （90%, 35 cases） in the observation group was better than that （72.5%, 29 patients） in control group （P〈0.05）.The average recovery time of serum β-HCG 35 of observation group was （14.5±7.7）d, less than that in control group （18.4±8.5）d （P〈0.05）.The mass narrowing of 32 cases in observation group in 3 weeks was better than that （21 cases） in control group.The clinical symptoms disappeared in 34 cases in observation group within 2 weeks was superior than 23 cases in control group （P〈0.05）. Conclusion： GFC combined with methotrexate and mifepristone improves the success rate of conservative treatment of ectopic pregnancy, and safe for clinical use.

关 键 词：异位妊娠 保守治疗 桂枝茯苓胶囊 甲氨蝶呤 米非司酮 

分 类 号：R287[医药卫生—中药学]