反复呼吸道感染与小儿支气管哮喘发作相关性分析  

Relationship between acute exacerbation of bronchial asthma and repeated respiratory tract infections in children

作　　者：李增清[1] 陈永新[1] 邹有群[1] 陈琳[1] 谭玉玉[1] 

机构地区：[1]广东省医学科学院广东省人民医院儿科一区,广东广州510080

出　　处：《中华医院感染学杂志》2013年第6期1397-1399,共3页Chinese Journal of Nosocomiology

摘　　要：目的分析小儿支气管哮喘急性发作与反复呼吸道感染之间的关系,以期对支气管哮喘预防治疗提供支持依据。方法选择53例哮喘急性发作期患儿(观察组)及68例哮喘缓解期患儿(对照组)作为研究对象,对其常规进行深部痰培养和病原学检查,并对各项结果进行对比分析。结果观察组有12例患儿合并有反复呼吸道感染,占22.64%,对照组合并呼吸道反复感染患儿3例,占4.41%,两组差异有统计学意义(P<0.01);观察组患儿发生呼吸道感染47例,感染率为88.68%,检出革兰阴性菌占59.57%,革兰阳性菌占40.43%,对照组发生感染13例,感染率为19.11%,检出革兰阴性菌占53.85%,革兰阳性菌占46.15%,两组差异有统计学意义(P<0.05);观察组中革兰阴性菌主要为肺炎克雷伯菌占21.27%,流感嗜血菌17.02%,对照组革兰阴性菌主要为肺炎克雷伯菌15.39%、流感嗜血菌15.39%,差异有统计学意义(P<0.05);观察组革兰阳性菌主要为肺炎链球菌占19.15%、金黄色葡萄球菌17.02%,对照组革兰阳性菌主要为肺炎链球菌23.07%、金黄色葡萄球菌15.39%,差异有统计学意义(P<0.05)。结论哮喘急性发作与反复呼吸道感染关系密切,呼吸道细菌感染可能是小儿哮喘急性发作的重要诱因。OBJECTIVE To analyze the relationship between the repeated respiratory tract infections and acute exacerbation of asthma in children so as to provide references for the prevention and treatment of bronchial asthma. METHODS A total of 53 children with acute exacerbation of asthma （the observation group） and 68 children in asthma clinical remission（the control group） were selected as the research objects. The routine deep sputum culture and the etiological examination were performed, and the results were compared. RESULTS There were 12 （22.64%） children with the repeated respiratory infections in the observation group, 3 （4.41%） cases in the control group, the difference was statistically significant （P〈0.01）; there were 47 （88.68%） eases with respiratory tract infections in the observation group,the detection rate of the gram-negative bacteria was 59.57 %; and the detection rate of the gram-positive bacteria was 40.43 %; there were 13 （19.11%） cases with respiratory tract infections in the control group, the detection rate of the gram-negative bacteria was 53. 85%, and the detection rate of the gram-positive bacteria was 46.15 %, the difference was statistically significant（P〈0.05）. In the observation group Klebsiella pneumoniae （21. 27%） and Haemophilus influenzae （17. 02%） were the predominant species of the gram-negative bacteria, and in the control group K. pneumoniae （15. 39%） and H. influenzae（15. 39%） were the predominant species of the gram-negative bacteria, the difference was statistically significant （P 〈 0. 05）. In the observation group Streptococcus pneumoniae （19. 15%） and Staphylococcus aureus （17.02%） were the leading species of the gram-positive bacteria , and the in the control group S. pneumoniae （23. 07%） and S. aureus （15. 39%） were dominant in the gram-positive bacteria, the difference was statistically significant （P〈0.05）. CONCLUSION The acute exacerbation of asthma in children is closely related to the repeate

关 键 词：支气管哮喘 小儿 反复呼吸道感染 

分 类 号：R181.32[医药卫生—流行病学]