钱桐荪教授经验方对糖尿病肾病大鼠晚期糖基化终末产物受体蛋白的影响  

The effect of Qian Tongsun's experienced recepi on receptor for advanced glycation end products in diabetic nephropathy

作　　者：邓志丹 朱欣航[2] 钱桐荪[2] 

机构地区：[1]江苏省常州市肿瘤医院肾脏内科,常州213001 [2]南通大学附属医院风湿免疫科

出　　处：《南通大学学报（医学版）》2013年第1期43-46,共4页Journal of Nantong University(Medical sciences)

摘　　要：目的:观察钱桐荪教授中药经验方(下称钱氏经验方)对糖尿病肾病模型的早期防治效果及对晚期糖基化终末产物受体(receptor for advanced glycation end products,RAGE)表达的影响。方法:采用腹腔注射链脲佐菌素(strepto-zotoc in,STZ)诱导糖尿病模型,造模成功随机将成模动物分为糖尿病模型组、钱氏经验方大剂量组、钱氏经验方小剂量组,各组灌胃8周,于8周末检测24 h尿蛋白,免疫组化及Western Blot检测肾小球RAGE表达情况。结果:糖尿病观察组的24 h尿蛋白定量、RAGE表达明显高于正常组,钱氏经验方大剂量组和钱氏经验方小剂量组24 h尿蛋白定量、RAGE表达明显低于糖尿病观察组。结论:钱氏经验方可能通过降低RAGE的表达对糖尿病肾病起防治作用。Objective： To investigate the effect of Qian Tongsun＇s experienced recepi （Qian-shi experienced recepi） on the early prevention of Diabetic Nephropathy models and on the expression of receptor of advanced glycosylation end products （RAGE）. Methods： Peritoneal injection with streptozotoein（STZ） to induce diabetic model,and then randomly divided into three groups：diabetic model group, high-dose group of Qian-shi experienced recepi, low-dose group of Qian-shi experienced re-cepi. Every group intragastric administration eight weeks. To detect 24 hours urinary protein in the end of eight weeks and the RAGE expression of glomerular by hnmunohistochemistry and Western Blot. Results： 24 hours urinary protein and the ex-pressing of RAGE in Diabetic Nephropathy models were significantly higher than normal controls, both of them in low-dose group of Qian-shi experienced recepi and high-dose group of Qian-shi experienced recepi were apparently lower than dia-betic nephropathy group. Conclusions： Qian-shi experienced recepi could prevent the progress of diabetic nephropathy ,per-haps by decreasing the expression of RAGE.

关 键 词：糖尿病肾病 晚期糖基化终末产物受体蛋白 钱酮荪教授中药经验方 

分 类 号：R587.2[医药卫生—内分泌]