P-糖蛋白及其逆转肿瘤细胞多药耐药性的研究进展  

P-glycoprotein and the Research Progress on Reversal of P-glycoprotein-mediated Multidrug Resistance of Tumor Cells

作　　者：王清[1] 刘倩[1] 张学梅[1] 

机构地区：[1]大连大学医学院,辽宁大连116622

出　　处：《中国执业药师》2013年第3期33-36,56,共5页China Licensed Pharmacist

基　　金：国家科技支撑计划项目课题(2009BAK61B04)

摘　　要：随着化疗药物的广泛使用,肿瘤多药耐药性是导致化疗失败的主要原因之一。而P-糖蛋白(P-gp)介导的多药耐药性已成为目前的研究热点,本文就P-gp的结构、组织分布、P-gp介导的肿瘤细胞的多药耐药性及其逆转的研究现状作一综述。With the wide use of chemotherapy drugs, multidrug resistance （MDR） is considered as one of the major reasons causing chemotherapy failure. The multidrug resistance mediated by P-glycoprotein （P-gp） has recently become a hot research topic. This paper briefly introduced the structure and organization distribution of P-gp and the research progress of P-gp mediated multidrug resistance of tumor cells and its reversal strategy.

关 键 词：P-糖蛋白 肿瘤细胞 多药耐药性 

分 类 号：R915[医药卫生—微生物与生化药学]