国产甲型H_1N_1流行性感冒疫苗接种一年后的现场流行病学效果分析  

Analysis on the Epidemiological Effects of One Year after Vaccination of Influenza A(H_1N_1)Vaccination

作　　者：麦浩[1] 龙虎[1] 李荣成[2] 

机构地区：[1]桂林市疾病预防控制中心,广西壮族自治区桂林541001 [2]广西壮族自治区疾病预防控制中心,南宁530028

出　　处：《中国疫苗和免疫》2013年第1期47-48,93,共3页Chinese Journal of Vaccines and Immunization

摘　　要：目的分析国产甲型H1N1流行性感冒(甲流)疫苗接种一年后的流行病学效果。方法用随机抽样方法,应用队列研究,观察封闭单位内接种甲流疫苗者(接种组)和未接种甲流疫苗者(对照组)在一起甲流爆发疫情中罹患率的差异,以疫苗保护率和保护效果指数分析甲流疫苗的流行病学效果。结果接种组305人,未接种组622人,均为男性,接种组与对照组年龄构成差异无统计学意义,具有可比性。接种一年后发生甲流爆发疫情,报告流感样病例118例,罹患率12.73%。接种组甲流罹患率8.20%,低于对照组的罹患率(14.95%),差异有统计学意义(2=8.41,P=0.004)。疫苗保护率为45.15%,保护效果指数1.83。结论国产甲流疫苗接种一年后仍有较好的保护效果。Objective To analysis the epidemiological effects of influenza A （HIN1） vaccine one year after Vaccination of Influenza A （H1N1） Vaccination. Methods Choose a closed unit, to find out the difference of incidence between group of vaccinated domestic influenza A （ H1N1 ） vaccine control group by cohort study in an outbreak after one year vaccination. The epidemiological effect were evaluated through the vaccine protection rate and the protection index. Results 305 vaccinated person, and 622 person in cotrol group were male, age composition in vaccine group and control group hadn＇t statistical signficance. There was an influenza A（HlNl）outbreaks after the vaccine was vaccinated one year. 118 inmates fell ill, with 12.73 % incidence rate. The incidence of vaccination group is 8.20%, which is lower than control group which is 14.95%, there is significant difference （X^2=8.41, P=0.004）.The protective rate of influenza A （H1N1 ）vaccine was 45.18 %, and the protection index was 1.83. Conclusion It still has well effective index of domestic influenza A （H1N1） vaccine one year after vaccination.

关 键 词：甲型H1N1流行性感冒疫苗 流行病学效果 

分 类 号：R186[医药卫生—流行病学] R511.5[医药卫生—公共卫生与预防医学]