2,3-二甲基喹啉类化合物的合成及其生物活性  

Synthesis and Biological Activity of 2,3-dimethylquinoline Derivatives

作　　者：范文玉[1] 姜艾汝[1,2] 田俊峰[2] 郝树林[2] 徐英[2] 李志念[2] 

机构地区：[1]沈阳化工大学,沈阳110142 [2]沈阳化工研究院有限公司新农药创制与开发国家重点实验室,沈阳110021

出　　处：《农药》2013年第3期171-173,共3页Agrochemicals

基　　金：国家重点基础研究发展规划项目(973项目:2010CB126105;2010CB735601;2012CB724501);国家"十二五"科技支撑计划项目(2011BAE06B00;2011BAE06B01;2011BAE06B02;2011BAE06B03;2011BAE06B05)

摘　　要：[目的]喹啉类化合物具有广泛的生物活性,寻找更好的高活性化合物并进行先导结构优化。[方法]以取代的2,3-二甲基-4-羟基喹啉作为中间体,利用中间体衍生化方法进行合成。[结果]合成了喹啉酯、喹啉醚及喹啉胺3类新化合物,其结构得到了NMR的表征和确认。[结论]生测结果表明,部分目标化合物对水稻稻瘟病、小麦白粉病有较好的防效。Quinolines possess a broad spectrum of biological activity,the purpose of this article is to search for better compound with high activity and then to carry out optimization around the lead structure.[Methods] The intermediate derivatization methods was adopted to synthesize the target compounds based on 2,3-dimethyl-4-hydroxy quinoline as intermediates.[Results] Quinoline ester,quinoline ether and quinoline amines were synthesized in this paper.All structures of the synthesized compounds were confirmed by 1H NMR.[Conclusions] Preliminary bioassay indicated that,some synthesized compounds have good fungicidal activities against Rice Blast and Wheat powdery mildew.

关 键 词：喹啉 中间体衍生化方法 生物活性 

分 类 号：TQ450.6[化学工程—农药化工]