高血压患者共病负性情绪联合抗抑郁剂治疗对照研究  

Control Study on Negative Emotion in Patients with Hypertension Joint of Antidepressive Drugs

作　　者：杨靖 马闯胜 邱国松[2] 邵玉单 

机构地区：[1]河南省郑州市第八人民医院,中国450006 [2]武警河南总队医院

出　　处：《中国健康心理学杂志》2013年第3期344-345,共2页China Journal of Health Psychology

摘　　要：目的探讨抗抑郁剂对高血压病患者焦虑、抑郁情绪,日常生活能力及血压的影响。方法将90例高血压共病焦虑抑郁症状的患者随机分为两组各45例,两组均给予常规降压药物治疗,研究组同时联合抗抑郁剂治疗,观察6周,于治疗前及治疗2周、6周末采用汉密尔顿抑郁量表(HAMD)(24项)、汉密尔顿焦虑量表(HAMA)、日常生活能力量表(ADL)进行评定,同时监测血压。结果研究组HAMD、HAMA、ADL评分治疗2周即有下降(tHD=2,01,tHA=1.94,tAD=2.14;P<0.05),6周时较治疗前显著下降(tHD=3.24,tHA=4.26,tAD=2.86;P<0.01),且较对照组下降更显著(tHD=218.63,tHA=11.55,tAD=5.13;P<0.01);6周末两组血压均较治疗前显著下降(t舒=2.94,3.25,t收=3.89,4.14;P<0.01),研究组较对照组下降更显著(t=2.56,3.51;P<0.01)。结论抗抑郁剂能有效改善高血压病患者的焦虑、抑郁症状,提高其日常生活能力,控制高血压指数。Objective To explore the clinical, efficacy of antidepressive drugs in the treatment of anxious and depressive mood and daily life ability and blood pressure in patients with hypertension. Methods Totally 90 hypertensive patients accompanied with anxiety and depression were randomly divided into research group（n=45,receiving routine anti-hypertensive drug and antidepres- sive drug）and control group（n= 45 ,only receiving routine antihypertensive drug treatment）for 6 weeks. All the patients were as sessed with Hamilton Depression Rating Scale for Depression （ARSD--24）and Hamilton Anxiety Scale （HAMA）and Activity of Daily Living Scale（ADL）,and blood pressure was measured regularly at baseline,week 2 and 6,respectively. Results At the end of week 2 after treatment,the scores of ARSD,HAMA and ADL were lower significantly compared with pretreatment （tAn = 2,01, tHA= 1.94 ,tAD = 2. 14 ,all P〈0.05）in research group ,and were lower significantly compared with pretreatment （tAR=3. 24 ,tHA 4. 26,tAD = 2. 86,P〈 0. 01）in research group at after 6 week treatment ,and were lower significantly in research group than in con- frol group （tAn = 218. 63 ,tHA=11. 55 ,tAD=5. 13 ,P〈0.01 ）. The blood pressure dicreased in both groups after treatment （t = 2.94, 3.25,t = 3.89,4.14 ,all P〈O. 01 ）, and d icreased more in research group than in control group （t = 2.56,3.51 ,all P〈O. 01 ）. Con- clusion Antidepressive drugs can improve anxious,depressive mood and blood pressure of hypertensive patients. It also significant- ly improves the daily life ability of hypertensive patients.

关 键 词：抗抑郁剂 高血压病 抑郁 焦虑 日常生活能力 

分 类 号：R544.1[医药卫生—心血管疾病]