蔗渣木聚糖磷酸酯-壳聚糖水凝胶的制备及其药物缓释作用  

Preparation of bagasse xylan phosphate-chitosan hydrogel and drug release effect

作　　者：李和平[1] 胡杨[1] 杨官威[1] 杨永哲[1] 张垚[1] 

机构地区：[1]桂林理工大学化学与生物工程学院有色金属及材料加工新技术教育部重点实验室,广西桂林541004

出　　处：《化学研究与应用》2013年第3期399-406,共8页Chemical Research and Application

基　　金：桂林市科学研究与技术开发项目(20110105-3);广西自然科学基金项目(桂科自0832258);广西研究生教育创新计划项目(2011105960817M20)

摘　　要：以蔗渣木聚糖磷酸酯和壳聚糖为主要原料,三聚磷酸钠为离子交联剂,制备了蔗渣木聚糖磷酸酯-壳聚糖水凝胶,并用SEM、IR表征了其结构。考察了影响制备及水凝胶粒子应用的因素,探讨了诸因素对水凝胶性能的影响。通过正交试验,分别得出两种方法制备水凝胶的优化条件:在pH=1.7的缓冲溶液中,蔗渣木聚糖磷酸酯浓度为0.10g/mL,壳聚糖浓度为0.04g/mL,三聚磷酸钠的浓度为0.20g/mL,成膜时间120min,用直接造粒法;在pH=6.8的缓冲溶液中,蔗渣木聚糖磷酸酯浓度为0.10g/mL,壳聚糖浓度为0.04g/mL,三聚磷酸钠浓度为0.20g/mL,成膜时间为90min,用间接造粒法。在优化制备条件下,通过模拟十二指肠缓冲溶液,得出在pH 4.8、三聚磷酸钠浓度为0.20mol/L时,水凝胶的载药量和药物释放行为较佳。Bagasse xylan phosphate-ehitosan hydrogel was prepared with bagasse xylan phosphate and ehitosan as the main raw ma- terials and the sodium trpolyphosphate was employed as ion cross-linking agent. The structure of the hydrogel was characterized by IR, SEM. The optimized reaction conditions were achieved as follows：tbe concentration of bagasse xylan phosphate, chitosan and so- dium trpolyphate were respectively 0. 10g/mL,0. 04g/mL,0. 20g/mL in pH = 1.7 buffer solution with direct granulation method, re- action time 120min;the concentration of bagasse xylan phosphate, chitosan and sodium trpolyphate were respectively 0. 10g/mL, 0. 04g/mL,0. 20g/mL at pH=6. 8 buffer solution with indirect granulation method,reaction time 90min. Under these optimum pre- pared conditions, the drug loading and drug release behavior of hydrogel were better through the simulation duodenum solution in O. 20mol/L sodium tripolyphosphate solution at pH 4. 8.

关 键 词：蔗渣木聚糖磷酸酯 水凝胶 壳聚糖 药物缓释 

分 类 号：O636.1[理学—高分子化学]