环已二胺铂(Ⅱ)类配合物跨人红细胞膜动力学研究  

The Kinetic Studies of Across-Erythrocyte Membrane Transport of 1,2 cyclohexanediamine Platinum(Ⅱ) Complexes

作　　者：安芳[1] 王书华[1] 邹娟[2] 陈宝卫[2] 

机构地区：[1]张家口医学院化学教研室,张家口075000 [2]北京医科大学无机化学教研室,北京100083

出　　处：《无机化学学报》2000年第4期680-682,共3页Chinese Journal of Inorganic Chemistry

摘　　要：In the synthetic plasma, the uptake kinetics of sulfato 1,2 cyclohexanediamine platinum(Ⅱ) , selenato 1,2 cyclohexanediamine platinum(Ⅱ) , squarato 1,2 cyclohexanediamine platinum(Ⅱ) , demethylcantharato 1,2 cyclohexanediamine platinum(Ⅱ) , oxalato 1,2 cyclohexanediamine platinum(Ⅱ) , malonato 1,2 cyclohexanediamine platinum(Ⅱ) , butanedioicato 1,2 cyclohexanediamine platinum(Ⅱ) across human erythrocyte membrane transport have been studied. The experiment results showed that the across membrance transport of all the platinum? complexes followed a first order kinetic process. The rate constants of seven 1,2 cyclohexanediamine platinum? were determined. The uptake rates were related to the hydrolysis rate. The complexes of larger hydrolysis rate have the larger rate constant. The hydrolysis complexes with charge is considered to differ from the neutral complexes in the passages across erythrocyte membranes.In the synthetic plasma, the uptake kinetics of sulfato 1,2 cyclohexanediamine platinum(Ⅱ) , selenato 1,2 cyclohexanediamine platinum(Ⅱ) , squarato 1,2 cyclohexanediamine platinum(Ⅱ) , demethylcantharato 1,2 cyclohexanediamine platinum(Ⅱ) , oxalato 1,2 cyclohexanediamine platinum(Ⅱ) , malonato 1,2 cyclohexanediamine platinum(Ⅱ) , butanedioicato 1,2 cyclohexanediamine platinum(Ⅱ) across human erythrocyte membrane transport have been studied. The experiment results showed that the across membrance transport of all the platinum? complexes followed a first order kinetic process. The rate constants of seven 1,2 cyclohexanediamine platinum? were determined. The uptake rates were related to the hydrolysis rate. The complexes of larger hydrolysis rate have the larger rate constant. The hydrolysis complexes with charge is considered to differ from the neutral complexes in the passages across erythrocyte membranes.

关 键 词：人红细胞膜 动力学 环已二胺铂配合物 抗癌药 

分 类 号：R979.1[医药卫生—药品] R969.1[医药卫生—药学]