胎兔骨髓基质细胞修复骨缺损的实验研究  

Experimental Study on Repair of Bone Defect with Cultured Fetal Rabbit Bone Marrow Stromal Cells

作　　者：张银刚[1] 杨述华[1] 罗怀灿[1] 李进[1] 

机构地区：[1]同济医科大学附属协和医院骨科，武汉 430022

出　　处：《同济医科大学学报》2000年第5期432-433,共2页Acta Universitatis Medicinae Tongji

基　　金：湖北省自然科学基金资助科题 (No.99J130)

摘　　要：为了证实体外培养的胎兔骨髓基质细胞可以修复骨缺损 ,将培养的基质细胞吸附于明胶海绵 ,植入兔骨缺损处 ,1、 2、 4、 6、 8周作 99m Tc- MDP骨显像、X片、组织切片观察骨痂生长情况。结果显示 ,平均 4周左右实验组骨缺损得到修复 。In order to study the in vitro cultured feral rabbit bone marrow stromal cells for repair of bone defect, the cultured stromal cells adsorbed on gelatin sponge were planted into bone defect of rabbit radius. At first, 2nd, 4th, 6th and 8th week, 99m Tc MDP imaging, x ray examination and histopathological observation were performed to observe the callus growth. The results showed that in the experimental group the bone defect was repaired at 4th week. It was suggested that fetal rabbit bone marrow stromal cells could be used as seeds to repair bone defect.

关 键 词：胎兔 骨髓基质细胞 骨缺损 修复 实验研究 

分 类 号：R687.3[医药卫生—骨科学] R318.08[医药卫生—外科学]