复方附苓颗粒的制备工艺研究  

Study on Preparation Technology of Compound Fuling Granule

作　　者：陶方方[1] 沈敏鹤[2] 蒋亚奇[1] 黄瑛[1] 吴巧凤[1] 

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]浙江省中医院,浙江杭州310000

出　　处：《中华中医药学刊》2013年第3期559-562,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药管理局科技计划项目(2005C140)

摘　　要：目的:优选复方附苓颗粒的制备工艺。方法:采用L9(34)正交试验设计,以乌头碱和齐墩果酸的含量及浸膏得率为评价指标,优选复方附苓颗粒的制备工艺。结果:最佳制备工艺为:加10倍量75%的乙醇,回流提取2次,提取时间为1 h。结论:优选的制备工艺操作简便,稳定可行,重复性好,可为该制剂的生产提供理论依据。Objective：To optimize the preparation technology of Compound Fuling Granule.Methods：The contents of aconitine and oleanolic acid and extraction ratio were used as indexes to optimize the preparation technology of compound prescription granule by orthogonal design of L9（3^4）.Results：The optimal preparation technology was as follows：extracted with 75% alcohol for 2 times,1 h for each time and ratio of lipuid to solid was 10∶ 1.Conclusion：The optimized preparation technology was simple,stable,feasible and reproducible,and it can provide a theoretical basis for the production of this preparation.

关 键 词：复方附苓颗粒 正交试验 制备工艺 

分 类 号：R284.1[医药卫生—中药学]