小剂量他达拉非降阶梯治疗心因性勃起功能障碍  

Low-dose daily de-escalatory administration of tadalafil for psychological erectile dysfunction

作　　者：黄存超[1] 梁季鸿[1] 李广裕[1] 梁世坤[1] 宋卫儒[1] 张迅[1] 韦国强[1] 朱春晖[1] 韦平 陈云斌[1] 

机构地区：[1]广西医科大学第一附属医院男性学科,广西南宁530021 [2]来宾市兴宾区计划生育服务站,广西来宾546100

出　　处：《中华男科学杂志》2013年第3期241-246,共6页National Journal of Andrology

摘　　要：目的:探讨小剂量他达拉非降阶梯治疗对心因性勃起功能障碍的疗效。方法:采用勃起功能国际指数问卷(IIEF-5)、勃起硬度分级评分(EHS)。将门诊诊断为心因性勃起功能障碍共84例患者随机分小剂量他达拉非降阶梯治疗组(观察组,n=42)、按需治疗组(对照组,n=42)治疗2个月,进行治疗前后及组间对比评分。结果:对照组5例失访共79例完成观察研究。两组治疗后IIEF-5评分、EHS较治疗前均明显提高。观察组、对照组治疗ED有效率分别达95.2%、86.5%,与对照组相比,观察组有更高的有效率以及依从性(P<0.05)。结论:他达拉非对心因性勃起功能障碍具有良好作用,小剂量他达拉非降阶梯治疗优于按需治疗。Objective： To investigate the effect of low-dose daily de-escalatory administration of tadalafil on psychological erectile dysfunction （ED）. Methods ： We randomized 84 psychological ED patients into an observation and a control group of equal num- ber to receive low-dose daily de-escalatory administration and on-demand medication of tadalafil, respectively, both for 2 months. We compared the scores on IIEF-5 and erection hardness （EHS） between the two groups before and after the treatment. Results： The treatment and follow-up were accomplished for 79 cases, with 5 withdrawals in the control group. The IIEF-5 and EHS scores were remarkably improved in both the observation and control groups after treatment. The rate of therapeutic effectiveness was significantly higher in the observation group than in the control （95.2% vs 86.5%, P 〈 0.05）. Conclusion ： Low-dose daily de-escalatory administration of tadalafil is highly effective and even better than on-demand medication of tadalafil for psychological ED.

关 键 词：勃起功能障碍 他达拉非 小剂量 心因性 降阶梯治疗 

分 类 号：R698.1[医药卫生—泌尿科学]