艾塞那肽对高原地区血糖控制不佳2型糖尿病患者的疗效  

Efficiency of exenatide in treatment of type 2 diabetes mellitus patients with inadequately controlled blood glucose in plateau area

作　　者：邓永明[1] 李素芝[1] 陈仕迅[1] 李川[1] 邹密[1] 龚运兵[1] 黄勤[2] 王奇金[2] 

机构地区：[1]西藏军区总医院肾脏内分泌科,拉萨850000 [2]第二军医大学长海医院内分泌科,上海200433

出　　处：《第二军医大学学报》2013年第3期341-343,共3页Academic Journal of Second Military Medical University

基　　金：上海市自然科学基金(09ZR1400700)~~

摘　　要：目的观察艾塞那肽对高原地区血糖控制不佳的2型糖尿病患者的疗效。方法选择二甲双胍、磺脲类药物或胰岛素治疗后血糖控制不佳的2型糖尿病患者18例,在原有治疗方案的基础上加用艾塞那肽注射液治疗3个月,监测患者空腹血糖(FBG)、餐后2h血糖(2hPBG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、体质量等指标的变化。结果艾塞那肽治疗3个月后,患者FBG、2hPBG、HbA1c、体质量指数,血脂TG、TC、LDL-C水平均较治疗前降低(P<0.05)。结论艾塞那肽能有效控制高原地区2型糖尿病患者血糖,降低患者体质量指数,并改善血脂水平。Objective To observe the efficiency of exenatide in treatment of type 2 diabetes mellitus patients with inadequately controlled blood glucose in plateau area. Methods Eighteen type 2 diabetes mellitus patients whose blood glucose was not well controlled by metformin, sulfonylureas or insulin therapy were selected in this study. Exenatide was added to the original therapy for 3 months, and the changes of fasting blood glucose （FBG）, 2 h postprandial blood glucose （2hPBG）, glycosylated hemoglobin （HbAlc）, blood lipid levels （TG, TC, LDL-C, HDL-C）, and body weight were observed. Results After 3 months of treatment with exenatide, FBG, 2hPBG, HbA1c, body mass index, and blood lipid levels （TG, TC, LDL-C ） were significantly reduced as compared with those before treatment （P〈0. 05）. Conclusion Exenatide can effectively control blood glucose, decrease body mass index, and improve the blood lipid level in type 2 diabetes mellitus patients living in plateau area.

关 键 词：2型糖尿病 艾塞那肽 高海拔 血糖 

分 类 号：R587.1[医药卫生—内分泌]