放射治疗分次间与分次中眼晶状体的位移研究  

Research on inter-fraction and intra-fraction motion of crystalline lens in radiotherapy

作　　者：杨书明[1] 赵水喜[2] 穆晓峰[1] 赵卫东[1] 宁健[1] 

机构地区：[1]武警总医院肿瘤放疗中心,北京100039 [2]武警总医院肿瘤一科,北京100039

出　　处：《解放军医学杂志》2013年第3期222-224,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：目的探讨眼晶状体在放射治疗分次间与分次中的运动范围。方法对17例头颈部肿瘤患者的CT和MRI图像进行配准,勾画晶状体轮廓,分别确定中心坐标位置,进一步模拟分析分次间与分次中的晶状体位移。结果左右晶状体在分次中与分次间均有不同程度的位移。与分次中运动幅度相比,在左右、前后和头脚方向上分次间晶状体运动的幅度均较大。结论在自由状态下进行放射治疗时,不考虑摆位误差影响,仅以分次间与分次中运动幅度而论,晶状体的计划危及器官应在晶状体外延1.5mm为宜。Objective To investigate the range of inter-fraction and intra-fraction motion of crystalline lens in radiotherapy. Methods The CT and MRI images of 17 patients were registered, and the profile of crystalline lens was delineated to determine the respective center coordinates, thus simulating and analyzing inter-fraction and intra-fraction motion of lens in radiotherapy. Results Both left and right lens moved in different degree during both inter- or intra-fraction phase. The range of lens movement was larger in inter-fraction than in intra-fraction phase in all directions. Conclusion When radiotherapy is given in the free state, considering the distance of lens movement alone in inter- and intra-fraction and without considering the setup error, the lens planning organs at risk should increase 1.5mm outside the lens boundary.

关 键 词：图像配准 放射疗法 放射治疗计划 计算机辅助 晶体 

分 类 号：R818.05[医药卫生—放射医学]