ACE、CYP11B2和α-ADDUCIN基因多态性与福建汉族高血压相关性的分析  

Association between ACE,CYP11B2 and α-ADDUCIN gene polymorphisms and hypertension in fujian chinese population

作　　者：林慧中[1] 陈慧[2] 吴小盈[2] 陈燕 李德育[2] 陈喜军[2] 

机构地区：[1]福建医科大学附属协和医院心内科,福建福州350004 [2]福建省立医院,福建福州350003 [3]厦门中山医院,福建厦门361000

出　　处：《基础医学与临床》2013年第4期429-433,共5页Basic and Clinical Medicine

基　　金：福建省自然科学基金重点资助项目(C0420003)

摘　　要：目的研究血管紧张素转换酶(ACE)基因(I/D)、醛固酮合成酶(CYP11B2)基因-344T/C、α-内收蛋白(α-ADDUCIN)基因460G/T多态性的联合作用与福建汉族原发性高血压的关系。方法入选福建汉族1 380例高血压患者及888例正常对照者,采用聚合酶链反应-限制性内切酶片段长度多态性技术(PCR-RFLP)检测3个基因的基因型,分析3个基因多态性与高血压的相关性。结果 ACE-DD+ADDUCIN-TT基因型和ACE-DD+CYP11B2-TC/CC基因型在高血压组分布频率较高(P<0.05),OR(95%CI)值分别为1.81(1.09,3.01),P<0.05;1.61(1.15,2.27),P<0.01。ACE-DD+CYP11B2-TC/CC+ADDUCIN-TT基因型在高血压组分布频率较高(P<0.05),OR(95%CI)值为2.82(1.41-5.65),P<0.01。结论 ACE-DD、ADDUCIN-TT、CYP11B2-TC/CC联合基因型与高血压发病有关。高血压的发生,可能是多个基因协同作用的结果。Objective The aim is to investigate the association between ACE, CYP11B2 and α-ADDUCIN gene pol- ymorphisms and primary hypertensive subjects. Methods A total of 1380 essential hypertension and 888 normal controls were surveyed in Fujian Chinese population. The genotype for ACE, CYP11B2 and α-ADDUCIN were de- termined by polymerase chain reaction （PCR）and restriction fragment length polymorphism （RFLP）. Results In muhigene analysis, the frequencies of ACE-DD ＋ ADDUCIN-TT genotype and ACE-DD ＋ CYPI 1B2-TC/CC genotype were significantly higher in hypertension group than in control group （P 〈 0. 05 ）, OR （95 % CI）were 1.81 （ 1.09, 3.01 ） （ P 〈 0. 05 ） and 1.61 （1.15,2.27） （ P 〈 0. 01 ） respectively ; the frequencies of ACE-DD ＋ CYPllB2-TC/CC ＋ ADDUCIN-qT genotype was significantly higher in hyperten-sion group than control group （P 〈 0.05 ） , OR（ 95% CI） was2.82 （1.41- 5.65）, （P〈0.01）. Conclusions ThecombinedgenotypeACE-DD, ADDUCIN-TTandCYP11B2-TC/CC might be related with hypertension. It is possible that muhigenes were interacted in the etiology of hypertension.

关 键 词：血管紧张素转换酶 醛固酮合成酶 Α-内收蛋白 基因多态性 原发性高血压 

分 类 号：R544.1[医药卫生—心血管疾病] R394.3[医药卫生—内科学]