MMP-9 R279Q基因多态性与冠心病易感性的Meta分析  

MMP-9 R279Q polymorphism and susceptibility to coronary heart disease: a meta-analysis

作　　者：陈卫强[1] 王浩然 张健[1] 齐向前[1] 

机构地区：[1]天津医科大学心血管病临床学院泰达国际心血管病医院心内科,天津300457 [2]国家心血管病中心中国医学科学院北京协和医学院阜外心血管病医院心血管疾病国家重点实验室,北京100037

出　　处：《基础医学与临床》2013年第4期467-471,共5页Basic and Clinical Medicine

摘　　要：目的探讨MMP-9 R279Q基因多态性与冠心病易感性的关系。方法检索PubMed,获取2012-01-01以前发表的MMP-9 R279Q基因多态性与冠心病易感性的病例-对照研究。以冠心病组与对照组人群基因型分布的OR值及95%CI为效应指标,在纯合子比较模型、显性模型和隐性模型中采用固定效应方法进行合并分析,并进行偏倚评估,应用STATA11.0软件进行统计学处理。结果共纳入文献5篇,在MMP-9 R279Q基因多态性位点,基因型比较模型中合并OR值为0.925(95%CI=0.847-1.009),纯合子比较模型合并OR值为0.866(95%CI=0.713-1.052),显性模型合并OR值为0.909(95%CI=0.809-1.020),隐性模型合并OR值为0.902(95%CI=0.750-1.086)。结论 MMP-9 R279Q基因多态性可能与冠心病易感性无关。Objective To investigate the relationship between matrix metalloproteinase-9 （MMP-9） gene polymor- phism and genetic susceptibility to coronary heart disease. Methods A meta-analysis on MMP-9 R279Q polymor- phism and susceptibility to coronary heart disease was performed by searching for studies included in PubMed before January 1 2012. For each study, odds ratios （ORs） and 95% confidence intervals （CIs） was calculated to assume homozygote comparison, dominant and recessive genetic models. Pooled ORs and 95% CIs was calculated and pub- lication bias was assessed. All statistical analyses were conducted by STATA 11.0 software. Results A total of 5 case-control studies were analyzed in the study. The MMP-9 R279Q QQ genotype was not associated with the risk of coronary heart disease compared with R279Q RR genotype （QQ vs RR： OR =0. 866; 95% CI =0. 713 - 1. 052）. Effect estimates from a dominant model [ （QQ ＋ RQ） vs RR：OR = 0. 909; 95% CI =0. 809 - 1. 020] or a reces- sive model [ QQ vs （RQ ＋ RR）：OR =0. 902; 95% CI = 0. 750 -1. 086 ] suggest that the MMP-9 R279Q variants are not associated with coronary heart disease risk. Conclusions MMP-9 R279Q gene polymorphism may not be as-sociated with genetic susceptibility to coronary heart disease.

关 键 词：MMP 冠心病 基因多态性 M eta分析 

分 类 号：R541.4[医药卫生—心血管疾病]