Allergin-1在过敏性疾病发病机制中的作用  

Roles of Allergin-1 in the pathogenesis of allergic diseases

作　　者：张宇[1] 姚煦[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,南京210042

出　　处：《国际皮肤性病学杂志》2013年第2期95-97,共3页International Journal of Dermatology and Venereology

基　　金：国家自然科学基金（81171501）;江苏省自然科学基金（BK2011127）

摘　　要：肥大细胞脱颗粒是ⅠI型过敏反应的主要事件，IgE与肥大细胞上高亲和力IgE受体结合后导致肥大细胞脱颗粒，产生组胺、花生四烯酸及白三烯等过敏介质，产生一系列的过敏症状。肥大细胞膜上抑制性受体Allergin-1和高亲和力IgE受体交联后抑制高亲和力IgE受体胞内免疫受体酪氨酸抑制基序信号传导，可能产生免疫受体酪氨酸抑制基序抑制信号，参与调节肥大细胞脱颗粒，阻断过敏性炎症发生。As a major event in type Ⅰ allergic reaction, degranulation of mast cells is triggered by the interaction between specific IgEs and high affinity IgE receptors （FcεRIs） on mast cell membrane, and is followed by the release of a battery of inflammatory mediators, such as histamine, leukotrienes and arachidonic acid, and these inflammatory mediators in turn induce a series of allergic symptoms. Recently, Allergin-1 has been found to be an immunoglobulin-like receptor preferentially expressed on mast ceils. The crosslinking of Allergin-1 to FceRIs on mast cells may inhibit the signal transduction from FcεRIs to intracellular immunoreceptor tyrosine-based inhibitory motif （ITIM）, generate ITIM inhibitory signals, which then participate in the regulation of mast cell degranulation, and finally block the initiation of allergic inflammation.

关 键 词：变应原 Allergin-1 肥大细胞 

分 类 号：R593[医药卫生—内科学]