树突细胞在特应性皮炎发病中的研究进展  

Roles of dendritic cells in the pathogenesis of atopic dermatitis： an update

作　　者：邓小蓉[1] 宋志强[1] 郝飞[1] 

机构地区：[1]第三军医大学西南医院皮肤科,重庆400038

出　　处：《国际皮肤性病学杂志》2013年第2期110-112,共3页International Journal of Dermatology and Venereology

基　　金：国家自然科学基金（81072447）

摘　　要：特应性皮炎是一种慢性复发性炎症性皮肤病，具有血清IgE水平升高、Th2型免疫过度反应以及对多种病原微生物易感性增加等特点。研究表明，朗格汉斯细胞和表皮炎症样树突细胞是在特应性皮炎皮损中出现的两种树突细胞。其中表皮炎症样树突细胞是炎症性皮肤病所特有的一种树突细胞，仅在炎症性皮肤中表达，被激活后可释放大量炎症因子和趋化因子，而在皮炎得到成功控制后逐步消失。在特应性皮炎的病理生理机制中，表皮炎症样树突细胞不仅在炎症的持续和发展中起着重要作用，还可能与皮损局部Th2反应向Th1反应漂移有关。Atopic dermatitis （AD） is a chronic, recurrent and inflammatory skin disease characterized by increased serum IgE levels, predominance of T-helper cell type 2 （Th2） immune response, and elevated susceptibility to various pathogenic microorganisms. Studies have shown that there are two kinds of dendritic cells, including inflammatory dendritic epidermal cells （IDECs） and Langerhans cells, in AD lesions. IDECs specifically exist in inflammatory skin disease, and are exclusively expressed in inflamed skin. Moreover, activated IDECs may release various inflammatory cytokines and chemotactic factors, and gradually disappear after the control of dermatitis. In the pathophysiology of atopic dermatitis, IDECs not only play important roles in the maintenance and progression of inflammation, but also are associated with the shift from Th2 to Thl immune response in skin lesions of atopic dermatitis.

关 键 词：皮炎 特应性 树突细胞 受体 IGE 受体 组胺H4 

分 类 号：R758[医药卫生—皮肤病学与性病学]