微透析技术在皮肤药代动力学研究中的应用进展  

Appfication of microdialysis technique in dermatopharmacokinetic research

作　　者：吴黎莉[1] 陈沄法 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所药物研究室,南京210042

出　　处：《国际皮肤性病学杂志》2013年第2期131-134,共4页International Journal of Dermatology and Venereology

基　　金：中央级公益院所基本科研业务费专项基金（YZ-08-01）

摘　　要：经皮微透析是一种独特的在体取样技术，可测定真皮及皮下组织中游离药物浓度，是获得以真皮为作用靶位的药物实时动力学数据的首选方法。在局部皮肤屏障异常或存在皮损的情况下，进行药物经皮渗透性研究方面具有独特的优势。在过去的几十年里该技术发展迅速并被证明是一种用途广泛、安全、有效的皮肤外用制剂药代动力学与药效学研究工具。但该方法的重现性、探针植入与由此引起的组织损伤之间的确切关系，以及如何更简便地适用于脂溶性药物的研究等方面仍需深入研究。Cutaneous microdialysis is a unique technique for in vivo examination of unbound drug concentrations in dermis and subcutaneous tissues. Whenever the dermis is the target tissue of topical treatment, dermal mierodialysis （DMD） is the first choice for acquisition of real-time kinetic data. It has unique advantages for the research on topical drug penetration into skin with impaired harrier or lesions. In the past decades, this technique has developed quickly and proved to he a widely applicable, safe, and efficient tool for dermatopharmacokinetic and pharmacodynamie research into topical drugs. However, further research is warranted to evaluate the reproducibility of microdialysis as well as the exact relationship between probe insertion and tissue damage, and to make this technique more applicable to studies into liposoluhle drugs.

关 键 词：药代动力学 微透析 外用药 

分 类 号：R285[医药卫生—中药学]