两种糖苷分子中4,6位羟基保护方法的对比  

Comparison of two protecting methods for hydroxyl-groups at C-4,6 of glucoside

作　　者：蒋爱琴[1] 方志杰[1] 赵成芳[1] 李小敏[1] 彭新华[1] 华万森[1] 

机构地区：[1]南京理工大学化工学院,南京210094

出　　处：《化学试剂》2000年第4期203-204,共2页Chemical Reagents

基　　金：国家教委留学基金;南京市人事局留学归国人员启动基金

摘　　要：以间硝基苯甲醛代替苯甲醛实现糖苷分子中 4,6位羟基的保护 ,合成了 4,6 -氧 -间硝基亚苄基 -α-D-葡萄糖甲苷 ,收率为 5 0 .8% ,测定了其核磁共振谱 ,并对这两种基团的保护方法进行了比较。Methyl 4,6 O m nitrobenzylidene α D glucopyranoside was synthesized by using m nitrobenzaldehyde as the protecting group instead of benzaldehyde to protect the hydroxyls at C 4 and C 6 of methyl α D glucopyranoside.The yield was 50 8%.The product was characterized by 1HNMR and 13 CNMR spectra.The two kinds of protecting method were compared.

关 键 词：间硝基苯甲醛 苯甲醛 葡萄糖甲苷 羟基保护 

分 类 号：O629.13[理学—有机化学]