创伤后应激障碍患者创伤暴露后不同时期静息脑功能初探  

A preliminary study of alterations in resting-state functional MRI in posttraumatic stress disorder patients following trauma in different periods

作　　者：李磊[1] 孙雅文[1] 王振[2] 秦玲娣[1] 苏珊珊[1] 万杰清[3] 周滟[1] 许建荣[1] 

机构地区：[1]上海交通大学医学院附属仁济医院放射科,上海200127 [2]上海交通大学医学院附属精神卫生中心,上海200030 [3]上海交通大学医学院附属仁济医院神经外科,上海200127

出　　处：《放射学实践》2013年第3期256-259,共4页Radiologic Practice

基　　金：国家自然科学基金(30800370);国家自然科学基金(81171325);上海市浦江人才计划(09PJ1408900);上海市科委医学引导项目(114119a0900)资助

摘　　要：目的:探讨创伤后应激障碍(PTSD)患者在创伤后不同时期静息态脑功能连接的变化,旨在进一步了解PTSD的发病机制。方法:12例PTSD确诊患者在创伤后2天和6个月后分别行静息态脑功能MRI检查,运用DPARSF软件进行以后扣带回为种子点的脑功能连接分析,采用配对t检验,P<0.05(AlphaSim校正)为差异有统计学意义。结果:与创伤暴露后2天比较,6个月后PTSD患者双侧内侧前额叶皮层/前扣带回、右侧前扣带回、左侧额上回和右侧额中回与后扣带回的功能连接显著降低(P<0.05)。结论:创伤暴露后内侧前额叶皮层、前扣带回与后扣带回的功能连接随着时间推移而降低,这一变化对于PTSD的发病可能有重要意义。Objective：Resting-state functional magnetic resonance imaging （fMRI） was used to investigate whether functional connectivity was altered in patients with post-traumatic stress disorder （PTSD） following trauma in different periods and tried to make a deeper understanding of the pathogenesis of PTSD. Methods：Posterior cingulate cortex connectivity was determined from 12 PTSD patients within 2 days and 6 months post trauma by DPARSF. Paired t test was used to observe the changes of functional connectivity,and two-tailed p-value of 0.05 （AlphaSim corrected） was considered statistically significant. Results： Compared with 2 days post trauma, the bilateral medial prefrontal cortex /anterior cinglulate cortex, right anterior cingulate cortex,left superior frontal gyrus and right middle frontal gyrus exhibited decreased connectivity significantly in 6 months post trauma in PTSD patients （P〈0.05, AlphaSim corrected）. Conclusion： These results suggest functional connectivity in the medial prefrontal cortex/anterior cingulate cortex decreases over time which may be a major risk factor predisposing people to develop PTSD.

关 键 词：创伤后应激障碍 功能磁共振成像 功能连接 后扣带回 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.2[医药卫生—诊断学]