垂直传播对乙肝病毒基因型分布的影响  

Influence of vertical transmission on the distribution of HBV genotypes

作　　者：蔡颖[1] 郑凯[2] 吴晓梅[1] 陈铭[2] 李学成[1] 李彦[2] 

机构地区：[1]解放军第324医院感染科,重庆400021 [2]第三军医大学西南医院中心实验室,重庆400038

出　　处：《免疫学杂志》2013年第4期337-340,共4页Immunological Journal

基　　金：成都军区医学科研基金资助(MB09011)

摘　　要：目的乙肝病毒基因型呈地域差异分布的原因尚不完全清楚,本研究旨在调查乙肝病毒基因型B与C在母婴垂直传播中的风险程度,并探明该种传播方式是否会引发不同乙肝病毒基因型在我国及周边区域南、北差异分布。方法针对以往研究累计获得的922例受乙肝病毒感染母亲的子代,采用Meta分析对B、C基因型在垂直转播中的风险进行更广泛和可靠的一致性评价;并采用卡方检验,分析比较南、北地区人群垂直传播对B、C基因型的差异造成影响。结果母婴垂直传播中基因型C的总体风险度要明显高于基因型B(RR=2.61>1,95%CI),卡方检验结果显示垂直传播更有利于乙肝病毒C基因型在北方人群中的传播(χ2=39.1,P<0.05)。结论该研究明确了不同基因型在母婴垂直传播中的风险是不同的,C基因型的垂直传播风险度高于B基因型,该传播方式是引起乙肝病毒基因型在南、北地区差异分布的主要因素之一。The reason for the graphical distribution discrepancy of different HBV genotypes remains obscure. The aim of this study was to investigate the risk of HBV genotype B and C in the vertical transmission, and clarify whether the transmission manner lead to graphical distribution discrepancy of the HBV genotypes between northern and southern area in China and surrounding region. According to the accumulated data from previous studies, we performed the Meta-analysis to 922 cases of infants born by the HBV-infected mothers, in order to more widely and accurately evaluate the risk of genotype B and C virus by vertical transmission. Meanwhile, we compared the genotype B and C transmissions between northern and southern cases by Chi-square test. The result showed that the risk of genotype C was significantly higher than that of genotype B by vertical transmission （RR=2.61〉1, 95% CI）, and Chi-square showed the vertical transmission promoted the prevalence of genotype C in the northern population, in comparison with the southern population （X^2=-39.1, P〈0.05）. Result suggested that the risk of vertical transmission for genotype C is higher, which should be one of the major reason for the distinct distribution of HBV genotypes between northern and southern area.

关 键 词：乙肝病毒 基因型 垂直传播 区域分布 

分 类 号：R512.62[医药卫生—内科学]