老年男性骨密度与左心室质量指数的相关性研究  

Association between bone mineral density and left ventricular mass index in elderly men

作　　者：魏雅楠[1] 陈陵霞[1] 苗懿德[1] 刘杰[1] 郏蓉[1] 

机构地区：[1]北京大学人民医院老年科,100044

出　　处：《中华老年医学杂志》2013年第3期253-255,共3页Chinese Journal of Geriatrics

摘　　要：目的探讨老年男性骨量与左心室质量指数的关系。方法老年男性370例，平均年龄（76．6±9．3）岁，测定血清生化指标，进行骨密度检测和超声心动图检查，左心室质量指数采用左心室质量／身高。’法计算所得，根据是否合并左心室肥厚分为：非左心室肥厚组23l例，左心室肥厚组139例，两组计量资料均数间比较用独立样本t检验，组问率或构成比比较X2。检验。多因素分析采用多元逐步回归法。结果血清肌酐水平左心室肥厚组（97．1±43．O）μmol／L，高于非左心室肥厚组（88．2±21．1）μmol／L（P〈O．05）；左心室肥厚组各腰椎骨密度低于非左心室肥厚组，第1腰椎（0．90±0．16）g／cm2与（O．95±0．21）g／cm2（P=0．05），第2腰椎（O．95±0．17）g／cm2与（1．01土0．20）g／cm2（P〈O．01），第3腰椎（O．99±0．19）g／cm2与（1．06士0．28）g／cm2（P〈O．01），左心室肥厚组腰椎平均骨密度低于非左心室肥厚组（O．97±0．18）g／cm2与（1_03±0．26）g／cm2（P〈O．05）；股骨骨量比较，左心室肥厚组近端Inter区、大转子骨密度低于非左心室肥厚组，Inter区（1．00±0．17）g／cm2与（1．05±0．22）g／cm2（P〈O．05）；大转子（O．64±0．1lg／cm2）与（O．67±0．17）g／cm2（P〈0．05）。以左心室质量指数为因变量，多元线性回归分析逐步筛选结果显示，体质指数（r=0．27，P％0．01）、腰椎骨密度（r=-0．20，P％0．01）、年龄（r=0．16，P〈0．01）和血清肌酐（r=0．15，P〈0．05）与左心室质量指独立相关。结论老年男性人群中，腰椎骨密度与左心室质量指数独立相关。Objective To investigate the association between bone mineral density （BMD） and left ventricular mass index （LVMI） in elderly men in Beijing. Methods Totally 370 elderly men with an average age of （76.6±9.3） years from the departments of gerontology were included. BMD, echocardiography measurements as well as blood chemistry were analyzed. LVMI was obtained by echocardiography. All the subjects were divided into two groups： nomLVH group （n= 231） and LVH group （n =139）. Differences in quantitative variables were tested by independent-sample t test. Multiple stepwise linear regression analysis were performed to identify determinants of LVMI. Results The serum creatinine concentration was significantly higher in LVH group than in non- LVH group [（97.1 =[= 43. 0）μmol/L, （88.2 ±21.1） μmol/L （P〈0.05）] Compared with non-LVH group, LVH group showed that the lumbar spine BMD （L1-L4） were significantly lower[Ll： （0.90 ±0.16） g/cm2 vs. （0.95±0.21） g/cm2,P：0.05; L2： （0.95±0.17） g/cmz vs. （1.01±0.20） g/ cm2 , P〈0.01; L3： （0.99q-0.19） g/cm2 vs. （1.06±0.28） g/cm2 , P〈0.01] as well as the lumbar spine total BMD [（0. 97±0.18） g/cm2 vs. （1.03±0.26） g/cm2 , P〈0.05]. The femur BMD was lower in the LVH group than in non-LVH group trochiter： （0.64q-0.11） g/cm2 vs. （0.67±0.17） g/cm2, P〈0.05; inter area： （1.00±0.17） g/cm2 vs. （1.05±0.22） g/cm2, P〈0.05]. Multiple stepwise linear regression analysis demonstrated that BMI （r：0.27, P〈0.01）, the lumbar spine BMD （r：--0.20,P^0.01）, age （r=0.16, P〈0.05）, serum creatinine （r：0.15, P^0.05） were independently correlated with LVMI. Conclusions In elderly men in Beijing, the lumbar spine BMD is an independent correlative factor for LVMI.

关 键 词：骨密度 肥大 左心室 

分 类 号：R543[医药卫生—心血管疾病] R580[医药卫生—内科学]