壳聚糖丝心蛋白包药微球的结构和释放性能研究  

STUDIES ON THE STRUCTURE AND CONTROLLED RELEASE OF CHITOSAN/FIBROIN MICROSPHERE INCLUSION DRUG

作　　者：彭湘红[1] 张俐娜[2] 潘雪龙 

机构地区：[1]华中理工大学汉口分校化工系,武汉430012 [2]武汉大学化学系,武汉430072 [3]昆山双鹤药业有限责任公司,江苏215315

出　　处：《高分子学报》2000年第4期502-505,共4页Acta Polymerica Sinica

基　　金：上海中金投资集团和中科院广州纤维素化学开放实验室资助

摘　　要：Miscibility of the fibroin, which was soluble in CaCl\-2\|H\-2O\|C\-2H\-5OH aqueous solution, mixed with chitosan was investigated, and its microspheres were prepared. The chitosan (CS)/fibroin (FB) microsphere inclusion fenoprofen calcium (CS\|FB\|FC) was prepared, and its structure was analyzed by FTIR, X\|ray and SEM. The results indicated that blend of chitosan, fibroin and fenoprofen calcium in aqueous solution is miscible, and strong interaction caused by intermolecular hydrogen bonding exits in CS\|FB\|FC. It was indicated that approximately 77% of fenoprofen from the microsphere were released in phosphate\|buffered saline(pH=7.4) within the initial 6h, and with increasing the glutaraldehyde concentration, the release of fenoprofen decreased.Miscibility of the fibroin, which was soluble in CaCl\-2\|H\-2O\|C\-2H\-5OH aqueous solution, mixed with chitosan was investigated, and its microspheres were prepared. The chitosan (CS)/fibroin (FB) microsphere inclusion fenoprofen calcium (CS\|FB\|FC) was prepared, and its structure was analyzed by FTIR, X\|ray and SEM. The results indicated that blend of chitosan, fibroin and fenoprofen calcium in aqueous solution is miscible, and strong interaction caused by intermolecular hydrogen bonding exits in CS\|FB\|FC. It was indicated that approximately 77% of fenoprofen from the microsphere were released in phosphate\|buffered saline(pH=7.4) within the initial 6h, and with increasing the glutaraldehyde concentration, the release of fenoprofen decreased.

关 键 词：壳聚糖 丝心蛋白 非诺洛芬钙 缓释 包药微球 

分 类 号：O636[理学—高分子化学]