睡眠时间不足致脂肪细胞因子分泌紊乱与肥胖相关性的研究进展  

Research progress of relationship between obesity and adipocytokine secretion disorder induced by short sleep duration

作　　者：陈婷[1] 张泽彧[1] 陈喆[1] 陈炉[1] 杨倩[1] 戴斐[2] 李生慧[2] 郑志杰[2] 

机构地区：[1]上海交通大学2010级预防医学本科,上海200025 [2]上海交通大学公共卫生学院预防医学教研室,上海200025

出　　处：《上海交通大学学报（医学版）》2013年第3期359-362,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81072314,30700670);上海市教委科研创新项目(13YZ034);上海交通大学医学院“新百人计划”;上海市公共卫生优秀学科带头人培养计划(GWDTR201222)~~

摘　　要：睡眠时间不足与肥胖作为重要的健康问题日益受到关注。最新研究资料提示,睡眠时间可能是肥胖发生和发展的重要影响因素。睡眠时间不足者,其体内多种脂肪细胞因子(瘦素、脂联素和内脂素等)的分泌量、分泌节律及其之间的动态平衡发生紊乱,进而可引发肥胖和胰岛素抵抗。文章以脂肪细胞因子为观察视角,对目前国内外关于睡眠时间不足与肥胖相关的机制研究进展作一概述,探讨多种脂肪细胞因子在睡眠和肥胖发生和发展中的作用。Both short sleep duration and obesity are global concerns threatening human health. Recent research data have indicated that sleep duration is an important influential factor for obesity. Short sleep duration disturbs the secretory volume and rhythm of adipocytokines such as leptin, adiponectin and visfatin, and interrupts the dynamic balance between them, after which obesity and insulin resistance may be triggered. This paper is to systematically review the existing domestic and international literatures on the related mechanisms between short sleep duration and obesity, and discuss the effect of several important adipocytokines on sleep and obesity.

关 键 词：肥胖 睡眠 脂肪细胞因子 

分 类 号：R589.2[医药卫生—内分泌]