荧光磁性纳米微球Dy_xFe_(3-x)O_4@PEGMA-Tb的制备、表征及其载药性研究  

Preparation,Characterization and Drug Loading Properties of Fluorescent-magnetic Nano-microsphere Dy_xFe_(3-x)O_4@PEGMA-Tb

作　　者：孟繁宗[1] 肖蓓蕾[1] 翟玉春[2] 

机构地区：[1]德州学院农学系,德州253023 [2]东北大学材料与冶金学院,沈阳110004

出　　处：《材料导报》2013年第4期97-103,共7页Materials Reports

基　　金：2010年度山东省自然科学基金(ZR2010EL014)

摘　　要：采用改进的化学共沉淀法制备了镝掺杂铁氧体磁流体DyxFe3-xO4,然后以甲基丙烯酸聚乙二醇酯(PEGMA)为单体,N,N′-亚甲基双丙烯酰胺(MBA)为交联剂,采用光化学方法在DyxFe3-xO4磁流体中制备了磁性甲基丙烯酸聚乙二醇酯微球,进而合成了含有稀土元素Tb的荧光磁性高分子微球(FMPMs)。用VSM、PCS、FTIR、TGA、SEM、FS等技术对FMPMs的性能进行了表征,并以丝裂霉素C(Mitomycin C,MMC)为药物模型,初步考察了FMPMs对MMC的载释性能。结果表明,荧光磁性高分子微球粒径较小,呈圆球形,具有超顺磁性和荧光性,分散性好;同时具有较高的载药量和包封率,体外药物释放受pH值影响较大,是靶向给药的良好载体。The Dy^3＋-doped ferrite magnetic fluids were synthesized by a improved chemical co-precipitation method, and magnetic nano-particles consisting of hydroxyl radicals were prepared by photochemical synthesis in the hydrophilic magnetic fluid DyxFe3-xO4, the monomer PEGMA（poly（ethylene glycol） methyl ether methacrylate） and the cross-linker MBA（N, N＇-methylene-bis-acrylamide）. Fluorescent magnetic polymer microspheres （FMPMs） con- taining Tb were synthesized and characterized by VSM, PCS, FTIR, TGA, SEM and FS. The drug loading-releasing property of FMPMs was analyzed with pharmaceutical model of mitomycin C. The results show that FMPMs has su- perparamagnetism, fluorescence, high dispersion and sphericity, high drug loading and embedding ratio, a great effect of relaxation ability in vitro on pH, a very remarkable magnetic responsibility, and therefore can be used as high-quali- ty drug carrier.

关 键 词：荧光磁性高分子微球 DyxFe3-xO4磁性液体 甲基丙烯酸聚乙二醇酯 光化学合成 载药性 

分 类 号：O632[理学—高分子化学]