床边检测氨基末端脑钠肽前体对急性呼吸困难的鉴别诊断价值  

The value of bedside testing of plasma NT-proBNP levels in differentiating etiology of acute dyspnea

作　　者：胡北[1] 叶珩[1] 孙诚[1] 何楷然[1] 曾红科[1] 

机构地区：[1]广东省医学科学院,广东省人民医院急危重症医学部,广州市510080

出　　处：《实用医学杂志》2013年第6期925-927,共3页The Journal of Practical Medicine

摘　　要：目的:探讨床边检测NT-proBNP对急性呼吸困难患者的鉴别诊断价值。方法:回顾性分析121例急性呼吸困难患者,行床边NT-proBNP检测,收集患者的年龄、性别、LVEF及诊断等指标并进行统计分析。结果:心源性呼吸困难患者79例,非心源性呼吸困难患者42例,NT-proBNP平均值分别为(5720.41±2912.15)pg/mL、(818.88±851.65)pg/mL,差异有统计学意义。NT-proBNP诊断心源性呼吸困难的AUCROC为0.952±0.018(95%CI0.918～0.987),截点值为1776.0pg/mL,敏感性为91.1%,特异性为90.5%。结论:床边检测NT-proBNP对急性心源性呼吸困难诊断敏感性强、特异性高,可作为急性呼吸困难鉴别诊断的重要指标。Objective To investigate the value of bedside testing of plasma NT-proBNP in differentiating etiology in patients with acute dyspnea. Methods A retrospective analysis was tan＇led out in 121 patients with acute dyspnea. Plasma NT-proBNP levels were measured by bedside. Patients＇age, gender, LVEF and diagnosis were recorded and analyzed statistically. Results NT-proBNP of patients with cardiac dyspnea and noncardiac dyspnea were （5 720.41±2 912.15） pg/mL and （818.88±851.65） pg/mL, respectively, the difference between which was statistically significant. Tile AUCROC of NT-proBNP in diagm）sing cardiac dyspnea was 0.952 ± 0.018 （95% CI 0.918 ±0.987）, the cut-off value was 1 776.0 pg/mL, sensitivity 91.1%, specificity 90.5%. Conclusion Bedside testing of NT-proBNP for diagnosis of acute cardiac dyspnea is of high sensitivity and specificity, and it can be used as indicators of the differential diagnosis of acute dyspnea.

关 键 词：急性呼吸困难 NT—proBNP 鉴别诊断 ROC曲线 

分 类 号：R541.6[医药卫生—心血管疾病]