益脉降压流浸膏对老年气虚血瘀证高血压病患者血浆神经肽Y含量的影响  

Effect of Yimai Jiangya Extract on Plasma Neuropeptide Y Level in Patients of Senile Hypertension with Qi Deficiency and Blood Stasis Syndrome

作　　者：段学忠[1] 杨丁友[1] 孙西庆[2] 李士林[1] 周次清[2] 

机构地区：[1]济南军区总医院,济南250031 [2]山东中医药大学

出　　处：《中国中西医结合杂志》2000年第10期750-752,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的 :观察益脉降压流浸膏对老年气虚血瘀证Ⅱ期高血压病患者血浆神经肽Y(NPY)含量的影响。方法 :将 68例患者随机分为两组 ,分别用益脉降压流浸膏 (治疗组 36例 )和卡托普利 (对照组 32例 )治疗 ;采用放射免疫法测定两组患者治疗前后血浆NPY含量。结果 :血浆NPY含量治疗前两组患者均较健康老年人显著升高 (P <0 0 1) ;治疗后均显著降低 (P <0 0 5或P <0 0 1) ,且治疗组优于对照组 (P <0 0 1)。血压 :两组患者治疗后比治疗前均下降 (P <0 0 1) ,但组间比较差异无显著性。结论 :老年气虚血瘀证高血压病患者存在血浆NPY含量增高 ;益脉降压流浸膏对其有较好的降低血浆NPY含量作用和良好的降压作用 。Objective: To observe the effect of Yimai Jiangya extract (YMJYE) on plasma neuropeptide Y (NPY) level in patients of senile hypertension at stage Ⅱ with Qi Deficiency and blood stasis Syndrome (QDBSS). Methods: Sixty eight patients were randomly divided into two groups, 36 patients in the treated group treated with YMJYE and 32 patients in the control group treated with captopine. Radioimmunoassay was used to examine the level of plasma NPY before and after treatment in the two groups. Results: Before treatment, plasma NPY level was significantly higher in both groups than that in the old healthy persons (P<0 01), it lowered significantly after treatment and the decrement was more obvious in the treated group in comparing with that in the control group (P<0 01). Blood pressure was significantly lowered in both groups after treatment (P<0 01) but with no significant difference between them. Conclusion: Plasma NPY level was increased in patients of senile hypertension with QDBSS. YMJYE had good effect in lowering plasma NPY level and reducing blood pressure. It is presumed that the NPY lowering effect of YMJYE might be one of its mechanisms in lowering blood pressure.

关 键 词：益脉降压流浸膏 高血压 气虚血瘀证 神经肽Y 

分 类 号：R259[医药卫生—中西医结合]