不同基质和促渗剂对川芎嗪凝胶经皮吸收的影响  

Effect of Different Matrices and Penetration Enhancers on Transdermal Absorption of Tetramethylpyrazine Gel

作　　者：卢映[1] 涂星[2] 吴俊洪[1] 吕耿彬[1] 陈豆[1] 陈晓丹[1] 黄雨威[1] 王利胜[1] 

机构地区：[1]广州中医药大学中药学院,广东广州510006 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《中药新药与临床药理》2013年第2期166-169,共4页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的考察不同基质和促渗剂对川芎嗪凝胶经皮吸收的影响。方法采用改良Franz扩散池,以离体裸鼠皮肤为屏障,用HPLC法测定不同基质(1%卡波姆、5%CMC-Na、5%HPMC)和不同促渗剂(氮酮、油酸、冰片和冰片-薄荷脑低共融物)对川芎嗪凝胶的累积渗透量、渗透吸收速率、增渗倍数等参数的影响。结果以1%卡波姆为基质时透皮吸收效果最好,几种促渗剂均可较好的促进川芎嗪凝胶的经皮吸收,尤以5%氮酮以及冰片-薄荷脑(3%∶3%)低共融物的促渗效果最佳。结论 1%卡波姆为最佳的凝胶基质,5%氮酮或者冰片-薄荷脑(3%∶3%)低共融物为川芎嗪凝胶最佳的促渗剂。Objective To study the effects of different matrices and penetration enhancers on the transdermal absorp- tion of the tetramethylpyrazine（TMP） gel. Methods Improved Franz diffusion cell was adopted as the apparatus for in-vitro nude mouse skin permeation. The kinetic parameters of percutaneous absorption, such as permeability amount, penetration rate and enhancing rate were determined by HPLC. Different matrices （1% carbopol, 5 % CMC-Na, 5 % HPMC） and different penetration enhancers such as azone, oleic acid（OA） borneol and borneol-men- tholum euctectic mixture were investigated in percutaneous absorption effects. Results The effect of the transdermal absorption of the TMP gel was the best when the matrix was 1% carbopol. All the penetration enhancers increases the absorption of the TMP gel significantly, in particular 5 % azone and 6 % borneol-mentholum euctectic mixture（3 % ： 3 % ）. Conclusion The optimal matrix is one percent of carbopol, and the optimal penetration enhancer is the five percent of azone or the six percent of borneol-mentholum euctectic mixture（3 % ： 3 % ）.

关 键 词：川芎嗪凝胶 基质 促渗剂 经皮吸收 高效液相色谱 

分 类 号：R285.5[医药卫生—中药学]