咪唑克生增强吲哚满酯在小鼠视觉暗示空间鉴别中的作用  

Idazoxan potentiates effects of TMDMC on the performance of visual cueing spatial discrimination in mice

作　　者：张中启[1] 韩颖 罗质璞[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850 [2]北京核二院职工医院,北京100840

出　　处：《中国药理学通报》2000年第4期441-443,共3页Chinese Pharmacological Bulletin

摘　　要：目的　探讨胆碱能系统与去甲肾上腺素能系统是否共同参与学习记忆过程。方法　小鼠视觉暗示空间鉴别法。结果　合用无效剂量的α2 受体拮抗剂咪唑克生和无效剂量的胆碱酯酶抑制剂吲哚满酯 ,明显促进小鼠视觉暗示空间鉴别的获得和再现。另外 ,咪唑克生与吲哚满酯一样 ,能完全翻转东莨菪碱对小鼠视觉暗示空间鉴别的损害作用。结论　咪唑克生能增强吲哚满酯的向智作用 ,表明胆碱能系统与去甲肾上腺素能系统交互作用 。AIM To explore whether there is a putative interaction of the cholinergic and noradrenergic systems in learning and memory process METH ODS The visual cueing spatial discrimination(VCSD) task was used RESULTS 5 (1,3,3 trimethylindolinyl) N,N dimethyl carbamate (TMDMC),an acetylcholinesterase inhibitor, in the subeffective doses (0 15～0 20 mg·kg -1 ), significantly potentiates the acquisition and the retrieval of VCSD when combined with the subeffective dose of α 2 receptor antagonist idazoxan (0 04 mg·kg -1 ) In addition, idazoxan (0 08 mg·kg -1 ), similar to TMDMC (0 5 mg·kg -1 ), completely reversed the impairment of the acquisition of VCSD induced by scopolamine (1 mg·kg -1 ) CONCLUSION Idazoxan can potentiate the neutropic effect of TMDMC, and the findings provide further support for the interaction of the cholinergic and noradrenergic systems in learning and memory process

关 键 词：吲哚满酯 咪唑克生 视觉暗示空间鉴别 

分 类 号：R971[医药卫生—药品]