氟西汀对大鼠海马脑源性神经营养因子基因表达的作用  

Effect of chronic fluxetine administration on expression of brain derived neurotrophic factors(BDNF) mRNA in hippocampal region of rat brain

作　　者：许珂[1] 张永亮[2] 郁缪宇 刘协和[1] 

机构地区：[1]华西医科大学附一院心理卫生研究所,广州市精神病医院成都610041 [2]华西医科大学法医学系,成都610043

出　　处：《中国药理学通报》2000年第4期453-455,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助课题 !No 396 70 2 72

摘　　要：目的　为了进一步探讨抗抑郁药作用的分子机制。方法　采用原位杂交技术 (地高辛标记的BDNFcDNA探针 )检测长期给予抗抑郁药氟西汀及生理盐水大鼠海马神经元BDNFmRNA的表达。结果　与生理盐水组相比 ,氟西汀组表达增强 ,尤以CA3、CA1区为甚。AIM To explore the molecular mechanism of antidepressant action of fluxetine. METHODS In situ hybridization technique (BDNF cDNA Probe labeled with digoxigenin) was used to examine the expression of BDNF mRNA in hippocampal neurons of rats after chronic administration of fluxetine and saline. RESULTS Contrary to saline group, the expression of BDNF mRNA was increased in fluxetine group, especially in CA3 and CA1 regions of hippocampus. CONCLUSION This change of BDNF in hippocampus induced by fluxetine may relate to its after receptor molecular mechanism of antidepressant effect.

关 键 词：氟西汀 脑源性神经营养因子 海马 原位杂交 

分 类 号：R971.4[医药卫生—药品]