芪蛭降糖胶囊治疗2型糖尿病早期下肢动脉硬化闭塞症104例  

Clinical study on the effect of Qizhi Jiangtang Capsule(a TCM formula) in treating 104 patients with diabetic lower limbs arteriosclerosis obliterans(ASO)

作　　者：莫爵飞[1] 闫秀峰[2] 倪青[2] 

机构地区：[1]中国中医科学院广安门医院外科,北京100053 [2]中国中医科学院广安门医院内分泌科,北京100053

出　　处：《环球中医药》2013年第2期105-110,共6页Global Traditional Chinese Medicine

基　　金：北京市科技计划课题(D08050703020802)

摘　　要：目的评价芪蛭降糖胶囊治疗2型糖尿病一、二期下肢动脉硬化闭塞症的临床疗效。方法将146例基线具可比性的一、二期2型糖尿病下肢动脉硬化闭塞症患者采用非随机同期对照研究,最终治疗组纳入104例,给予常规治疗加芪蛭降糖胶囊口服;对照组纳入42例,给予常规治疗,共观察12周。结果治疗组总有效率为93.27%,较对照组85.71%,差异具有显著性(P<0.05);与对照组相比,治疗组的症状积分异常显著改善,优于对照组,差异具有显著性(P<0.05);在缓解患者下肢发凉怕冷、酸胀和皮肤紫暗方面,在控制空腹和餐后2小时血糖在8～12周时均表现为优于对照组,且治疗12周后,HbA1c控制情况优于对照组;下肢多普勒超声检查结果也有明显改善(P<0.05)。结论芪蛭降糖胶囊对2型糖尿病一、二期下肢动脉硬化闭塞症有显著的治疗作用。Objective To evaluate the clinical efficacy of Qizhi Jiangtang Capsule （ a TCM formula） in treating type 2 diabetic lower limb arteriosclerosis obliterans （DLASO） of first stage or second stage. Methods 146 type 2 diabetes patients with comparable baseline with lower limb arteriosclerosis obliterans were, by method of non-randomized concurrent controlled trial, divided into two groups, i.e. the treatment group, in which 104 patients received conventional therapy plus Qizhi Jiangtang Capsule; and the control group, in which 42 patients were given conventional treatment, both were observed for 12 weeks. Results In the treatment group, the total effective rate was 93.27%, significantly higher than that of the control group （85.71% ） （P 〈 0. 05 ） ; Compared with the control group, the treatment group improved significantly abnormal symptom score, significantly better than that of the control group （ P 〈 0. 05 ） ; In alleviating cold feeling or aversion to coldness in the lower limbs, dark purple skin, soreness and distension sensations in the lower limbs, and in the control of fasting and 2h postprandial blood glucose at 8 -12 weeks, and HbAlc level at 12 weeks after treatment are all better than the control group （P 〈0.05） ; and most importantly, the lower limbs＇ Doppler ultrasound blood flow examination resuhs in both groups have been significantly improved, and results in treatment group are better than those in the control group （ P 〈 0. 05 ）. Conclusion Qizhi Jiangtang Capsule has significant therapeutic effect on diabetic diabetic lower limb arteriosclerosis obliterans （ASO） of first stage or second stage.

关 键 词：糖尿病下肢动脉硬化闭塞症 芪蛭降糖胶囊 治疗 中医药 

分 类 号：R587.2[医药卫生—内分泌]