托里消毒散对原发性肝癌栓塞化疗不良反应的对抗作用  

The Counteraction of Tuolixiaodu Powder on the Adverse Reactions Caused by Transcatheter Hepatic Arterial Chemoembolization in Treating Primary Hepatocarcinoma

作　　者：梁俊雄[1] 邝幸华[2] 吴永毅[2] 翁书和[2] 罗丹峰[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院,广州510120 [2]广州中医药大学第一附属医院,广州510405

出　　处：《北京中医药大学学报》2000年第5期56-57,共2页Journal of Beijing University of Traditional Chinese Medicine

基　　金：广东省中医药管理局科研基金!资助项目 (No .983 92 )

摘　　要：:将明确诊断为原发性肝癌并以Seldinger方法首次栓塞化疗的患者 ,于栓塞化疗后第 1天开始进行西医的常规处理 ,并加用化裁的托里消毒散 (由党参、北黄芪、茯苓、白术、甘草、白芍、当归、川芎、桔梗、白芷、金银花、皂角刺、白花蛇舌草等药物组成 )水煎汤剂内服 ,并设单纯西药治疗对照组。结果 :试验组的发热和其他症状的持续时间均较对照组缩短 ;常规肝功能的 4项指标 (血清总胆红素、直接胆红素、间接胆红素和碱性磷酸酶 )的值均比对照组低。提示托里消毒散对肝癌化疗栓塞术所致的大片组织坏死以及药物和栓塞引起的正气亏虚的副作用有拮抗作用 ,能减轻栓塞化疗引起的不良反应。The primary hepatocarcinoma patients, on the first day when they received the Seldinger's chemoembolization treatment for the first time, were divided into the western drug plus traditional Chinese drug (WDTCD) group and the western drug (WD) group. The traditional Chinese drug used in this study was a decoction prepared according to a modified formula named Tuolixiaodu Powder consisting of many traditional Chinese herbs (Codonopsis pilosula, Astragalus membranaceus or Astragalus membranaceus mongholicus, Poria cocos, Atractylodes macrocephala, Liquorice, Paeonia lactiflora, Angelica sinensis, Ligusticum chuanxiong, Platycodon grandiflorum, Angelica dahurica, Honeysuckle flower, Gleditsia sinensis, Hedyotis diffusa, etc.). The patients' symptoms of the fever, nausea, vomit, abdominal pain, hepatalgia and the patients' damage of hepatic functions all caused by the chemoembolization were treated with WDTCD and WD, respectively. The results showed that the lasting time of fever and other symptoms in WDTCD group was shorter than that in WD group ( P <0 01), and the values of the 4 routine indexes of hepatic functions (total bilirubin, direct bilirubin, indirect bilirubin and alkaline phosphatase in serum) in WDTCD group were all lower than those in WD group ( P <0 01), which implies that Tuolixiaodu Powder has antagonistic effects on the large area histological necrosis caused by the chemoembolization, and on the deficiency of vital qi caused by both the chemoembolization and some other drugs used in routine treatment of the hepatocarcinoma patients.

关 键 词：原发性肝癌 栓塞化疗 托里消毒散 中医药疗法 

分 类 号：R273.57[医药卫生—中西医结合]