不同体外循环回路对预充液舒芬太尼浓度的影响  

Effects of different types of extracorporeai circuits on concentrations of sufentanil in priming solution

作　　者：李芳[1] 高金贵[2] 

机构地区：[1]邢台市眼科医院麻醉科,054001 [2]河北医科大学第二医院麻醉科

出　　处：《中华麻醉学杂志》2013年第1期40-42,共3页Chinese Journal of Anesthesiology

基　　金：河北省科技计划项目（11276188）

摘　　要：目的评价不同体外循环回路对预充液舒芬太尼浓度的影响。方法实验分为3组（n=6）：西京90型大号鼓泡式氧合器体外循环回路组（I组）、Termo Capiox SX18成人膜式氧合器体外循环回路组（U组）和玻璃容器组（Ⅲ组）。将预充液（琥珀酰明胶液1000ml和乳酸钠林格氏液1000m1）预充人大号鼓泡式氧合器、膜式氧合器体外循环装置或玻璃容器中，从静脉贮血器的静脉端或玻璃容器口快速加入舒芬太尼15μg（浓度为7．5ng／ml）。于注入舒芬太尼后1、3、5、10、20、30、40、50、60、70、80、90min时，从静脉贮血器的动脉端或玻璃容器中抽取预充液1ml，采用气相色谱质谱法检测舒芬太尼的浓度。结果与Ⅲ组比较，Ⅰ组和Ⅱ组各时点预充液舒芬太尼浓度降低（P〈0．05）；与Ⅱ组比较，l组各时点预充液舒芬太尼浓度降低（P〈0．05）。结论西京90型大号鼓泡式氧合器和TermoCapioxSX18成人膜式氧合器体外循环回路对舒芬太尼均有吸附作用，且前者吸附作用强于后者。Objective To evaluate the effects of different types of extracorporeal circuits （ECCs） on the concentrations of sufentanil in the priming solution. Methods The experiment was performed in three groups （ n = 6 each） . Two types of ECCs were used： Xi-jing type 90 oxygenator （group 1 ） and Termo Capiox SXI 8 membrane oxygenator （group 11 ）, while in control group （ group III ） a glass container was used. The ECC and glass container were filled with the priming solution （succinylated gelatin 1000 ml ＋ lactated Ringer＇s solution 1000 ml）. Sufentanil 15 μg （concentration 7.5 ng/ml） was then added to the priming solution. The priming solution was circulated in the closed ECC or stirred in the glass container. The concentration of sufentanil in the priming solution was determined by gas chromatography-mass spectrometry at 3, 5, 10, 20, 30, 40, 50, 60, 70, 80 and 90 min after addition of sufentanil. Results The concentration of sufentanil in the priming solution was significantly decreased at the different time points in groups I and II as compared with group m （ P 〈 0.05）. The concentration of sufentanil in the priming solution was significantly lower at each time point in group I than in group II （ P 〈 0.05）. Conclusion Both the two types of ECCs can absorb sufentanil and the adsorption of Xi-jing type 90 oxy- genator is stronger than that of Termo Capiox SX18 membrane oxygenator.

关 键 词：体外循环 舒芬太尼 

分 类 号：R614[医药卫生—麻醉学]