高纬北极真菌Penicillium sp.C-5次级代谢产物的研究  

Preliminary study on natural products of the fungal strain Penicillium sp.C-5 from high latitude Arctic region

作　　者：周啟辉[1,2] 许丹[2] 樊成奇[3] 杨益平[4] 李会荣[2] 陈波[1,2] 

机构地区：[1]华东理工大学生物工程学院,上海200237 [2]中国极地研究中心国家海洋局极地科学重点实验室,上海200136 [3]中国水产科学研究院东海水产研究所,上海200090 [4]中国科学院上海药物研究所,上海201203

出　　处：《中国海洋药物》2013年第2期26-30,共5页Chinese Journal of Marine Drugs

基　　金：国家高技术研究发展计划(2012AA092105);海洋公益性行业科研专项经费项目(201005032-3);南北极环境综合考察与评估专项(CHINARE2012-01-06;CHINARE2013-04-02)资助

摘　　要：目的对分离自北极Ny-lesund地区径流沉积物中的1株真菌Penicilliumsp.C-5的抗真菌活性成分进行研究。方法采用柱层析和半制备型HPLC等多种色谱方法对其发酵产物进行分离纯化;运用MS、1 H-NMR和13 C-NMR等波谱方法,结合文献对照,确定化合物结构。结果从发酵液的乙酸乙酯萃取物中分得两个化合物,经鉴定为BE-31405和sordaricin。结论2个化合物均为首次从北极微生物中分离得到。Objective To investigate the antifungal compounds of the fungus Penicillium sp. （2-5 isolated from a runoff sediment sample collected from Ny-Alesund, Arctic. Methods The natural compounds were purified by column chromatography and semi- preparative HPLC. The structures were determined on the basis of MS,IH-NMR and 13C-NMR spectroscopic analyses and comparison with the literatures. Results Two sordarin derivatives named BE-31405 and sordaricin were derived from the ethyl acetate ex- tract of the fermentation broth. Conclusion The two compounds were isolated from Arctic microorgan- ism for the first time.

关 键 词：北极真菌 抗真菌活性 天然产物 

分 类 号：R931[医药卫生—生药学]